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dc.contributor.author
Ke, Zhonghe
dc.contributor.author
Mallik, Pramit
dc.contributor.author
Johnson, Adam B.
dc.contributor.author
Luna, Facundo
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Nevo, Eviatar
dc.contributor.author
Zhang, Zhengdong D.
dc.contributor.author
Gladyshev, Vadim N.
dc.contributor.author
Seluanov, Andrei
dc.contributor.author
Gorbunova, Vera
dc.date.available
2018-11-20T13:49:55Z
dc.date.issued
2017-10
dc.identifier.citation
Ke, Zhonghe; Mallik, Pramit; Johnson, Adam B.; Luna, Facundo; Nevo, Eviatar; et al.; Translation fidelity coevolves with longevity; Wiley Blackwell Publishing, Inc; Aging Cell; 16; 5; 10-2017; 988-993
dc.identifier.issn
1474-9718
dc.identifier.uri
http://hdl.handle.net/11336/64707
dc.description.abstract
Whether errors in protein synthesis play a role in aging has been a subject of intense debate. It has been suggested that rare mistakes in protein synthesis in young organisms may result in errors in the protein synthesis machinery, eventually leading to an increasing cascade of errors as organisms age. Studies that followed generally failed to identify a dramatic increase in translation errors with aging. However, whether translation fidelity plays a role in aging remained an open question. To address this issue, we examined the relationship between translation fidelity and maximum lifespan across 17 rodent species with diverse lifespans. To measure translation fidelity, we utilized sensitive luciferase-based reporter constructs with mutations in an amino acid residue critical to luciferase activity, wherein misincorporation of amino acids at this mutated codon re-activated the luciferase. The frequency of amino acid misincorporation at the first and second codon positions showed strong negative correlation with maximum lifespan. This correlation remained significant after phylogenetic correction, indicating that translation fidelity coevolves with longevity. These results give new life to the role of protein synthesis errors in aging: Although the error rate may not significantly change with age, the basal rate of translation errors is important in defining lifespan across mammals.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Wiley Blackwell Publishing, Inc
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Aging
dc.subject
Comparative Biology
dc.subject
Longevity
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Translation Fidelity
dc.subject.classification
Otras Ciencias Biológicas
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
Translation fidelity coevolves with longevity
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-10-23T14:10:48Z
dc.identifier.eissn
1474-9726
dc.journal.volume
16
dc.journal.number
5
dc.journal.pagination
988-993
dc.journal.pais
Reino Unido
dc.journal.ciudad
Londres
dc.description.fil
Fil: Ke, Zhonghe. University of Rochester; Estados Unidos
dc.description.fil
Fil: Mallik, Pramit. University of Rochester; Estados Unidos
dc.description.fil
Fil: Johnson, Adam B.. University of Rochester; Estados Unidos
dc.description.fil
Fil: Luna, Facundo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones Marinas y Costeras. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Instituto de Investigaciones Marinas y Costeras; Argentina
dc.description.fil
Fil: Nevo, Eviatar. University of Haifa; Israel
dc.description.fil
Fil: Zhang, Zhengdong D.. Albert Einstein College of Medicine; Estados Unidos
dc.description.fil
Fil: Gladyshev, Vadim N.. Harvard Medical School; Estados Unidos
dc.description.fil
Fil: Seluanov, Andrei. University of Rochester; Estados Unidos
dc.description.fil
Fil: Gorbunova, Vera. University of Rochester; Estados Unidos
dc.journal.title
Aging Cell
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.1111/acel.12628
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/full/10.1111/acel.12628
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