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dc.contributor.author Pasquare, Susana J.
dc.contributor.author Gaveglio, Virginia Lucía
dc.contributor.author Giusto, Norma Maria
dc.date.available 2016-07-12T18:48:28Z
dc.date.issued 2011-01
dc.identifier.citation Pasquare, Susana J.; Gaveglio, Virginia Lucía; Giusto, Norma Maria; Regulation of Phosphatidic Acid Metabolism by Sphingolipids in the Central Nervous System; Hindawi Publishing Corporation; Journal of Lipids; 2011; 1-2011; 1-18
dc.identifier.issn 2090-3030
dc.identifier.uri http://hdl.handle.net/11336/6456
dc.description.abstract This paper explores the way ceramide, sphingosine, ceramide 1-phosphate, and sphingosine 1-phosphate modulate the generation of second lipid messengers from phosphatidic acid in two experimental models of the central nervous system: in vertebrate rod outer segments prepared from dark-adapted retinas as well as in rod outer segments prepared from light-adapted retinas and in rat cerebral cortex synaptosomes under physiological aging conditions. Particular attention is paid to lipid phosphate phosphatase, diacylglycerol lipase, and monoacylglycerol lipase. Based on the findings reported in this paper, it can be concluded that proteins related to phototransduction phenomena are involved in the effects derived from sphingosine 1-phosphate/sphingosine or ceramide 1-phosphate/ceramide and that age-related changes occur in the metabolism of phosphatidic acid from cerebral cortex synaptosomes in the presence of either sphingosine 1-phosphate/sphingosine or ceramide 1-phosphate/ceramide. The present paper demonstrates, in two different models of central nervous system, how sphingolipids influence phosphatidic acid metabolism under different physiological conditions such as light and aging.
dc.format application/pdf
dc.language.iso eng
dc.publisher Hindawi Publishing Corporation
dc.rights info:eu-repo/semantics/openAccess
dc.rights.uri https://creativecommons.org/licenses/by/2.5/ar/
dc.subject PHOSPHATIDIC ACID
dc.subject SPHINGOLIPIDS
dc.subject SYNAPTOSOMES
dc.subject ROD OUTER SEGMENTS
dc.subject.classification Bioquímica y Biología Molecular
dc.subject.classification Ciencias Biológicas
dc.subject.classification CIENCIAS NATURALES Y EXACTAS
dc.title Regulation of Phosphatidic Acid Metabolism by Sphingolipids in the Central Nervous System
dc.type info:eu-repo/semantics/article
dc.type info:ar-repo/semantics/artículo
dc.type info:eu-repo/semantics/publishedVersion
dc.date.updated 2016-07-05T18:47:13Z
dc.journal.volume 2011
dc.journal.pagination 1-18
dc.journal.pais Egipto
dc.journal.ciudad El Cairo
dc.description.fil Fil: Pasquare, Susana J.. Consejo Nacional de Investigaciones Cientificas y Técnicas. Centro Científico Tecnológico Bahia Blanca. Instituto de Investigaciones Bioquímicas Bahia Blanca (i); Argentina. Universidad Nacional del Sur; Argentina
dc.description.fil Fil: Gaveglio, Virginia Lucía. Consejo Nacional de Investigaciones Cientificas y Técnicas. Centro Científico Tecnológico Bahia Blanca. Instituto de Investigaciones Bioquímicas Bahia Blanca (i); Argentina. Universidad Nacional del Sur; Argentina
dc.description.fil Fil: Giusto, Norma Maria. Consejo Nacional de Investigaciones Cientificas y Técnicas. Centro Científico Tecnológico Bahia Blanca. Instituto de Investigaciones Bioquímicas Bahia Blanca (i); Argentina. Universidad Nacional del Sur; Argentina
dc.journal.title Journal of Lipids
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/doi/10.1155/2011/342576
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1155/2011/342576
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/url/http://www.hindawi.com/journals/jl/2011/342576/


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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution 2.5 Unported (CC BY 2.5)