Mostrar el registro sencillo del ítem

dc.contributor.author
Rimondino, Guido Noé
dc.contributor.author
Miceli, E.
dc.contributor.author
Molina, M.
dc.contributor.author
Wedepohl, S.
dc.contributor.author
Thierbach, S.
dc.contributor.author
Rühl, E.
dc.contributor.author
Strumia, Miriam Cristina
dc.contributor.author
Martinelli, Marisa
dc.contributor.author
Calderón, M.
dc.date.available
2018-11-15T18:05:31Z
dc.date.issued
2017-01
dc.identifier.citation
Rimondino, Guido Noé; Miceli, E.; Molina, M.; Wedepohl, S.; Thierbach, S.; et al.; Rational design of dendritic thermoresponsive nanogels that undergo phase transition under endolysosomal conditions; Royal Society of Chemistry; Journal of Materials Chemistry B; 5; 4; 1-2017; 866-874
dc.identifier.issn
2050-750X
dc.identifier.uri
http://hdl.handle.net/11336/64556
dc.description.abstract
In the last few decades, the synthesis of nanodevices has become a very active research field with many applications in biochemistry, biotechnology, and biomedicine. However, there is still a great need for smart nanomaterials that can sense and respond to environmental changes. Temperature- and pH-responsive nanogels (NGs), which are prepared in a one-pot synthesis from N-isopropylacrylamide (NiPAm) and a Newkome-type dendron (ABC) bearing carboxylic acid groups, are being investigated as multi-responsive drug carriers. As a result, NGs have been developed that are able to undergo a reversible volume phase transition triggered by acidic conditions, like the ones found in endolysosomal compartments of cancer cells. The NGs have been thoroughly characterized using dynamic light scattering and spectroscopies, such as infrared, nuclear magnetic resonance, UV-visible, and stimulated Raman. Strong hydrogen bonds have been detected when the ABC moieties are deprotonated, which has led to changes in the transition temperatures of the NGs and a reversible, pH-dependent aggregation. This pH-dependent phase change was exploited for the effective encapsulation and sustained release of the anticancer drug cisplatin and resulted in a faster release of the drug at endolysosomal pH values. The cisplatin-loaded NGs have exhibited high toxicities against A549 cells in vitro, while the unloaded NGs have been found to be not cytotoxic and hemocompatible.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Royal Society of Chemistry
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Nanogels
dc.subject
Dendrons
dc.subject.classification
Nano-materiales
dc.subject.classification
Nanotecnología
dc.subject.classification
INGENIERÍAS Y TECNOLOGÍAS
dc.title
Rational design of dendritic thermoresponsive nanogels that undergo phase transition under endolysosomal conditions
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-11-02T15:11:30Z
dc.journal.volume
5
dc.journal.number
4
dc.journal.pagination
866-874
dc.journal.pais
Reino Unido
dc.journal.ciudad
Cambridge
dc.description.fil
Fil: Rimondino, Guido Noé. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; Argentina
dc.description.fil
Fil: Miceli, E.. Freie Universität Berlin; Alemania
dc.description.fil
Fil: Molina, M.. Freie Universität Berlin; Alemania
dc.description.fil
Fil: Wedepohl, S.. Freie Universität Berlin; Alemania
dc.description.fil
Fil: Thierbach, S.. Freie Universität Berlin; Alemania
dc.description.fil
Fil: Rühl, E.. Freie Universität Berlin; Alemania
dc.description.fil
Fil: Strumia, Miriam Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; Argentina
dc.description.fil
Fil: Martinelli, Marisa. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; Argentina
dc.description.fil
Fil: Calderón, M.. Freie Universität Berlin; Alemania
dc.journal.title
Journal of Materials Chemistry B
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.1039/C6TB02001A
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://pubs.rsc.org/en/Content/ArticleLanding/2017/TB/C6TB02001A


Archivos asociados

Documento no disponible

Comunidades y colecciones

Mostrar el registro sencillo del ítem