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dc.contributor.author Rimondino, Guido Noé
dc.contributor.author Miceli, E.
dc.contributor.author Molina, M.
dc.contributor.author Wedepohl, S.
dc.contributor.author Thierbach, S.
dc.contributor.author Rühl, E.
dc.contributor.author Strumia, Miriam Cristina
dc.contributor.author Martinelli, Marisa
dc.contributor.author Calderón, M.
dc.date.available 2018-11-15T18:05:31Z
dc.date.issued 2017-01
dc.identifier.citation Rimondino, Guido Noé; Miceli, E.; Molina, M.; Wedepohl, S.; Thierbach, S.; et al.; Rational design of dendritic thermoresponsive nanogels that undergo phase transition under endolysosomal conditions; Royal Society of Chemistry; Journal of Materials Chemistry B; 5; 4; 1-2017; 866-874
dc.identifier.issn 2050-750X
dc.identifier.uri http://hdl.handle.net/11336/64556
dc.description.abstract In the last few decades, the synthesis of nanodevices has become a very active research field with many applications in biochemistry, biotechnology, and biomedicine. However, there is still a great need for smart nanomaterials that can sense and respond to environmental changes. Temperature- and pH-responsive nanogels (NGs), which are prepared in a one-pot synthesis from N-isopropylacrylamide (NiPAm) and a Newkome-type dendron (ABC) bearing carboxylic acid groups, are being investigated as multi-responsive drug carriers. As a result, NGs have been developed that are able to undergo a reversible volume phase transition triggered by acidic conditions, like the ones found in endolysosomal compartments of cancer cells. The NGs have been thoroughly characterized using dynamic light scattering and spectroscopies, such as infrared, nuclear magnetic resonance, UV-visible, and stimulated Raman. Strong hydrogen bonds have been detected when the ABC moieties are deprotonated, which has led to changes in the transition temperatures of the NGs and a reversible, pH-dependent aggregation. This pH-dependent phase change was exploited for the effective encapsulation and sustained release of the anticancer drug cisplatin and resulted in a faster release of the drug at endolysosomal pH values. The cisplatin-loaded NGs have exhibited high toxicities against A549 cells in vitro, while the unloaded NGs have been found to be not cytotoxic and hemocompatible.
dc.format application/pdf
dc.language.iso eng
dc.publisher Royal Society of Chemistry
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject NANOGELS
dc.subject DENDRONS
dc.subject.classification Nano-materiales
dc.subject.classification Nanotecnología
dc.subject.classification INGENIERÍAS Y TECNOLOGÍAS
dc.title Rational design of dendritic thermoresponsive nanogels that undergo phase transition under endolysosomal conditions
dc.type info:eu-repo/semantics/article
dc.type info:ar-repo/semantics/artículo
dc.type info:eu-repo/semantics/publishedVersion
dc.date.updated 2018-11-02T15:11:30Z
dc.journal.volume 5
dc.journal.number 4
dc.journal.pagination 866-874
dc.journal.pais Reino Unido
dc.journal.ciudad Cambridge
dc.description.fil Fil: Rimondino, Guido Noé. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; Argentina
dc.description.fil Fil: Miceli, E.. Freie Universität Berlin; Alemania
dc.description.fil Fil: Molina, M.. Freie Universität Berlin; Alemania
dc.description.fil Fil: Wedepohl, S.. Freie Universität Berlin; Alemania
dc.description.fil Fil: Thierbach, S.. Freie Universität Berlin; Alemania
dc.description.fil Fil: Rühl, E.. Freie Universität Berlin; Alemania
dc.description.fil Fil: Strumia, Miriam Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; Argentina
dc.description.fil Fil: Martinelli, Marisa. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; Argentina
dc.description.fil Fil: Calderón, M.. Freie Universität Berlin; Alemania
dc.journal.title Journal of Materials Chemistry B
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.1039/C6TB02001A
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/url/https://pubs.rsc.org/en/Content/ArticleLanding/2017/TB/C6TB02001A
dc.conicet.fuente Elsevier


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info:eu-repo/semantics/restrictedAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)