Artículo
Zn(II) based novel potential drug containing sertraline as strong antidepressant agent
Escudero, Graciela; Laino, Carlos Horacio; Martini, Nancy
; Echeverría, Gustavo Alberto
; Piro, Oscar Enrique
; Williams, Patricia Ana María; Ferrer, Evelina Gloria
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Fecha de publicación:
02/2017
Editorial:
JSciMed Central
Revista:
Annals of Medicinal Chemistry and Research
ISSN:
2378-9336
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
A novel compound for depression treatment and other psychiatric disorders has been obtained being capable of displaying the combined benefitsof sertraline and an essential element such as zinc in order to get better antidepressant and negative side effects. Our working group has synthesized asalt formulation (SerH2)2+[ZnCl4]2- (C34H36N2Cl8Zn, sertralonium tetrachlorozincate(II)). The crystal structure was determined by X-ray diffraction methods. It crystallizes in the monoclinic P21 space group with a=7.3869(2) Å, b=13.2888(4) Å, c=19.3541(6) Å, β=96.596(3)° Å, β=91.792(4)°, and Z=2 molecules per unit cell. Their antidepressant activity in the forced swimming test (FST) proved to be stronger than the one shown by the commercial drug sertraline hydrochloride per se. Furthermore, this compound suppressed the anorexigenic effect caused by the antidepressant and showed an improvement in the assimilation time during in vitro fluorescence studies with bovine serum albumin. The results of this work have led to a patent application which was filed (Nº 20150103320) in Argentine country.
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Articulos(IFLP)
Articulos de INST.DE FISICA LA PLATA
Articulos de INST.DE FISICA LA PLATA
Citación
Escudero, Graciela; Laino, Carlos Horacio; Martini, Nancy; Echeverría, Gustavo Alberto; Piro, Oscar Enrique; et al.; Zn(II) based novel potential drug containing sertraline as strong antidepressant agent; JSciMed Central; Annals of Medicinal Chemistry and Research; 3; 1; 2-2017
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