Artículo
Proteomics, oxidative stress and male infertility
Fecha de publicación:
12/03/2014
Editorial:
Elsevier
Revista:
Reproductive Biomedicine Online
ISSN:
1472-6483
e-ISSN:
1472-6491
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Oxidative stress has been established as one of the main causes of male infertility and has been implicated in many diseases associated with infertile men. It results from high concentrations of free radicals and suppressed antioxidant potential, which may alter protein expression in seminal plasma and/or spermatozoa. In recent years, proteomic analyses have been performed to characterize the protein profiles of seminal ejaculate from men with different clinical conditions, such as high oxidative stress. The aim of the present review is to summarize current findings on proteomic studies performed in men with high oxidative stress compared with those with physiological concentrations of free radicals, to better understand the aetiology of oxidative stress-induced male infertility. Each of these studies has suggested candidate biomarkers of oxidative stress, among them are DJ-1, PIP, lactotransferrin and peroxiredoxin. Changes in protein concentrations in seminal plasma samples with oxidative stress conditions were related to stress responses and to regulatory pathways, while alterations in sperm proteins were mostly associated to metabolic responses (carbohydrate metabolism) and stress responses. Future studies should include assessment of post-translational modifications in the spermatozoa as well as in seminal plasma proteomes of men diagnosed with idiopathic infertility.
Palabras clave:
Biomarkers
,
Male Infertility
,
Proteomics
,
Oxidative Stress
Archivos asociados
Licencia
Identificadores
Colecciones
Articulos(IBYME)
Articulos de INST.DE BIOLOGIA Y MEDICINA EXPERIMENTAL (I)
Articulos de INST.DE BIOLOGIA Y MEDICINA EXPERIMENTAL (I)
Citación
Agarwal, Ashok; Durairajanayagam, Damayanthi ; Halabi, Jacques; Peng, Jason; Vazquez, Monica Hebe; Proteomics, oxidative stress and male infertility; Elsevier; Reproductive Biomedicine Online; 29; 1; 12-3-2014; 32-58
Compartir
Altmétricas