Show simple item record Buffone, Mariano Gabriel Wertheimer Hermitte, Eva Victoria Visconti, Pablo E. Krapf, Dario 2016-07-12T15:39:30Z 2014-07-24
dc.identifier.citation Buffone, Mariano Gabriel; Wertheimer Hermitte, Eva Victoria; Visconti, Pablo E.; Krapf, Dario; Central role of soluble adenylyl cyclase and cAMP in sperm physiology; Elsevier; Biochimica et Biophysica Acta - Molecular Basis of Disease; 1842; 12B; 24-7-2014; 2610-2620
dc.identifier.issn 0925-4439
dc.description.abstract Cyclic adenosine 3′,5′-monophosphate (cAMP), the first second messenger to be described, plays a central role in cell signaling in a wide variety of cell types. Over the last decades, a wide body of literature addressed the different roles of cAMP in cell physiology, mainly in response to neurotransmitters and hormones. cAMP is synthesized by a wide variety of adenylyl cyclases that can generally be grouped in two types: transmembrane adenylyl cyclase and soluble adenylyl cyclases. In particular, several aspects of sperm physiology are regulated by cAMP produced by a single atypical adenylyl cyclase (Adcy10, aka sAC, SACY). The signature that identifies sAC among other ACs, is their direct stimulation by bicarbonate. The essential nature of cAMP in sperm function has been demonstrated using gain of function as well as loss of function approaches. This review unifies state of the art knowledge of the role of cAMP and those enzymes involved in cAMP signaling pathways required for the acquisition of fertilizing capacity of mammalian sperm. This article is part of a Special Issue entitled: The role of soluble adenylyl cyclase in health and disease.
dc.format application/pdf
dc.language.iso eng
dc.publisher Elsevier
dc.rights info:eu-repo/semantics/openAccess
dc.subject AMPc
dc.subject KINASAS
dc.subject.classification Bioquímica y Biología Molecular
dc.subject.classification Ciencias Biológicas
dc.subject.classification CIENCIAS NATURALES Y EXACTAS
dc.title Central role of soluble adenylyl cyclase and cAMP in sperm physiology
dc.type info:eu-repo/semantics/article
dc.type info:ar-repo/semantics/artículo
dc.type info:eu-repo/semantics/publishedVersion 2016-06-15T19:10:38Z
dc.identifier.eissn 0006-3002
dc.journal.volume 1842
dc.journal.number 12B
dc.journal.pagination 2610-2620
dc.journal.pais Países Bajos
dc.journal.ciudad Amsterdam
dc.description.fil Fil: Buffone, Mariano Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina
dc.description.fil Fil: Wertheimer Hermitte, Eva Victoria. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos; Argentina
dc.description.fil Fil: Visconti, Pablo E.. University Of Massachussets; Estados Unidos
dc.description.fil Fil: Krapf, Dario. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Rosario. Instituto de Biología Molecular y Celular de Rosario; Argentina. Universidad Nacional de Rosario; Argentina
dc.journal.title Biochimica et Biophysica Acta - Molecular Basis of Disease
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/doi/10.1016/j.bbadis.2014.07.013
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/pmid/PMC4262597
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/doi/ 10.1016/j.bbadis.2014.07.013
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/url/
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/url/

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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)