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dc.contributor.author
Buffone, Mariano Gabriel
dc.contributor.author
Wertheimer Hermitte, Eva Victoria
dc.contributor.author
Visconti, Pablo E.
dc.contributor.author
Krapf, Dario
dc.date.available
2016-07-12T15:39:30Z
dc.date.issued
2014-07-24
dc.identifier.citation
Buffone, Mariano Gabriel; Wertheimer Hermitte, Eva Victoria; Visconti, Pablo E.; Krapf, Dario; Central role of soluble adenylyl cyclase and cAMP in sperm physiology; Elsevier; Biochimica et Biophysica Acta - Molecular Basis of Disease; 1842; 12B; 24-7-2014; 2610-2620
dc.identifier.issn
0925-4439
dc.identifier.uri
http://hdl.handle.net/11336/6441
dc.description.abstract
Cyclic adenosine 3′,5′-monophosphate (cAMP), the first second messenger to be described, plays a central role in cell signaling in a wide variety of cell types. Over the last decades, a wide body of literature addressed the different roles of cAMP in cell physiology, mainly in response to neurotransmitters and hormones. cAMP is synthesized by a wide variety of adenylyl cyclases that can generally be grouped in two types: transmembrane adenylyl cyclase and soluble adenylyl cyclases. In particular, several aspects of sperm physiology are regulated by cAMP produced by a single atypical adenylyl cyclase (Adcy10, aka sAC, SACY). The signature that identifies sAC among other ACs, is their direct stimulation by bicarbonate. The essential nature of cAMP in sperm function has been demonstrated using gain of function as well as loss of function approaches. This review unifies state of the art knowledge of the role of cAMP and those enzymes involved in cAMP signaling pathways required for the acquisition of fertilizing capacity of mammalian sperm. This article is part of a Special Issue entitled: The role of soluble adenylyl cyclase in health and disease.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Espermatozoide
dc.subject
Ampc
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Sperm Capacitation
dc.subject
Kinasas
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Bioquímica y Biología Molecular
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Ciencias Biológicas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.title
Central role of soluble adenylyl cyclase and cAMP in sperm physiology
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2016-06-15T19:10:38Z
dc.identifier.eissn
0006-3002
dc.journal.volume
1842
dc.journal.number
12B
dc.journal.pagination
2610-2620
dc.journal.pais
Países Bajos
dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Buffone, Mariano Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina
dc.description.fil
Fil: Wertheimer Hermitte, Eva Victoria. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos; Argentina
dc.description.fil
Fil: Visconti, Pablo E.. University Of Massachussets; Estados Unidos
dc.description.fil
Fil: Krapf, Dario. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Rosario. Instituto de Biología Molecular y Celular de Rosario; Argentina. Universidad Nacional de Rosario; Argentina
dc.journal.title
Biochimica et Biophysica Acta - Molecular Basis of Disease
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.bbadis.2014.07.013
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/ 10.1016/j.bbadis.2014.07.013
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/pmid/PMC4262597
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0925443914002257
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4262597/


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