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dc.contributor.author Gargiulo Monachelli, Gisella Mariana
dc.contributor.author Sivori, M.
dc.contributor.author Meyer, Maria
dc.contributor.author Sica, R. E. P.
dc.contributor.author de Nicola, Alejandro Federico
dc.contributor.author Gonzalez Deniselle, Maria Claudia
dc.date.available 2016-07-12T15:32:59Z
dc.date.issued 2014-05-07
dc.identifier.citation Gargiulo Monachelli, Gisella Mariana; Sivori, M.; Meyer, Maria; Sica, R. E. P.; de Nicola, Alejandro Federico; et al.; Circulating gonadal and adrenal steroids in amyotrophic lateral sclerosis: possible markers of susceptibility and outcome; Georg Thieme Verlag Kg; Hormone and Metabolic Research; 46; 6; 7-5-2014; 433-439
dc.identifier.issn 0018-5043
dc.identifier.uri http://hdl.handle.net/11336/6440
dc.description.abstract Although changes of circulating steroids have been reported in patients with sporadic amyotrophic lateral sclerosis (ALS), a full comparison of the adrenal and gonadal steroid profile between control subjects and ALS patients is lacking. Considering that respiratory failure is the most frequent cause of death in ALS, we looked into whether a relationship emerged between circulating steroids and respiratory parameters. Serum levels of adrenal and gonadal steroids were measured in 52 age- and gender-matched subjects (28 ALS and 24 controls) using radioimmunoassay techniques. We also evaluated respiratory parameters in ALS patients, including forced vital capacity (FVC), maximal inspiratory pressure (MIP), and maximal expiratory pressure (MEP). We found increased levels of testosterone in female ALS patients compared to healthy female subjects. Furthermore, control subjects showed a significant decline of testosterone, dehydroepiandrosterone and its sulfate, and a borderline decline of progesterone with increasing age. Instead, testosterone did not decline with increasing age in ALS patients. We also found that the dehydroepiandrosterone sulfate/cortisol ratio was positively associated with FVC, MIP, and MEP. Moreover, ALS patients showing higher testosterone levels and lower progesterone/free testosterone ratio presented a more rapid worsening of the monthly FVC. In conclusion, first our study revealed a differential steroid profile with age and gender in ALS patients relative to controls. Second, we demonstrated an association between some steroids and their ratios with respiratory function and disease progression. Thus, we hypothesize that the endogenous steroid profile could be a marker of susceptibility and prognosis in ALS patients.
dc.format application/pdf
dc.language.iso eng
dc.publisher Georg Thieme Verlag Kg
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject GONADAL STEROIDS
dc.subject ADRENAL STEROIDS
dc.subject MOTOR NEURON DISEASE
dc.subject AMYOTROPHIC LATERAL SCLEROSIS
dc.subject.classification Neurociencias
dc.subject.classification Medicina Básica
dc.subject.classification CIENCIAS MÉDICAS Y DE LA SALUD
dc.title Circulating gonadal and adrenal steroids in amyotrophic lateral sclerosis: possible markers of susceptibility and outcome
dc.type info:eu-repo/semantics/article
dc.type info:ar-repo/semantics/artículo
dc.type info:eu-repo/semantics/publishedVersion
dc.date.updated 2016-06-15T19:10:51Z
dc.identifier.eissn 1439-4286
dc.journal.volume 46
dc.journal.number 6
dc.journal.pagination 433-439
dc.journal.pais Alemania
dc.journal.ciudad Stuttgart
dc.description.fil Fil: Gargiulo Monachelli, Gisella Mariana. Gobierno de la Ciudad de Buenos Aires. Hospital Gral.de Agudos "ramos Mejia"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina
dc.description.fil Fil: Sivori, M.. Gobierno de la Ciudad de Buenos Aires. Hospital Gral.de Agudos "ramos Mejia"; Argentina
dc.description.fil Fil: Meyer, Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina
dc.description.fil Fil: Sica, R. E. P.. Universidad de Buenos Aires. Facultad de Medicina; Argentina
dc.description.fil Fil: de Nicola, Alejandro Federico. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana; Argentina
dc.description.fil Fil: Gonzalez Deniselle, Maria Claudia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina
dc.journal.title Hormone and Metabolic Research
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/doi/10.1055/s-0034-1371891
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1055/s-0034-1371891
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/pmid/24806746
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/url/https://www.thieme-connect.de/DOI/DOI?10.1055/s-0034-1371891


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info:eu-repo/semantics/restrictedAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)