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dc.contributor.author
Gasparoto, Thais Helena
dc.contributor.author
Ervolino de Oliveira, Carine
dc.contributor.author
Thomazini de Freitas, Luisa
dc.contributor.author
Ramos Pinheiro, Claudia
dc.contributor.author
Issa Hori, Juliana
dc.contributor.author
Pompermaier Garlet, Gustavo
dc.contributor.author
Cavassani, Karen Angélica
dc.contributor.author
Schillaci, Roxana
dc.contributor.author
Santana Da Silva, Joao
dc.contributor.author
Simmões Zamboni, Darío
dc.contributor.author
Campanelli, Ana Paula
dc.date.available
2016-07-12T15:05:48Z
dc.date.issued
2014-09-30
dc.identifier.citation
Gasparoto, Thais Helena; Ervolino de Oliveira, Carine; Thomazini de Freitas, Luisa; Ramos Pinheiro, Claudia; Issa Hori, Juliana; et al.; Inflammasome activation is critical to the protective immune response during chemically induced squamous cell carcinoma; Public Library of Science; Plos One; 9; 9; 30-9-2014; e107170-e107170
dc.identifier.issn
1932-6203
dc.identifier.uri
http://hdl.handle.net/11336/6438
dc.description.abstract
Chronic inflammation affects most stages of tumorigenesis, including initiation, promotion, malignant differentiation, invasion and metastasis. Inflammasomes have been described as involved with persistent inflammation and are known to exert both pro and antitumour effects. We evaluated the influence of apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC) and caspase (CASP)-1 in the antitumor immune response using a multistage model of squamous cell carcinoma (SCC) development. Absence of ASC and CASP-1 resulted in an earlier incidence and increased number of papilloma. Loss of inflammassome function in mice resulted in decreased presence of natural killer (NK), dendritic (DC), CD4+, CD8+ and CD45RB+ T cells in the tumor lesions as well as in lymph nodes (LN) compared with WT mice. Increased percentage of CD4+CD25+Foxp3+ T cells was associated with association with inflammasome loss of function. Moreover, significant differences were also found with neutrophils and macrophage infiltrating the lesions. Myeloperoxidase (MPO), but not elastase (ELA), activity oscillated among the groups during the SCC development. Levels of proinflammatory cytokines IL-1β, IL-18, Tumor Necrosis Factor (TNF)-α and Interferon (IFN)-γ were decreased in the tumor microenvironment in the absence of inflammasome proteins. These observations suggest a link between inflammasome function and SCC tumorigenesis, indicating an important role for inflammasome activation in the control of SCC development.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Public Library of Science
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by/2.5/ar/
dc.subject
Inflamosomes
dc.subject
Squamous Cell Carcinoma
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Papilloma
dc.subject
Skin Neoplasms
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Inmunología
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Inflammasome activation is critical to the protective immune response during chemically induced squamous cell carcinoma
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2016-06-15T19:09:44Z
dc.identifier.eissn
1932-6203
dc.journal.volume
9
dc.journal.number
9
dc.journal.pagination
e107170-e107170
dc.journal.pais
Estados Unidos
dc.journal.ciudad
San Francisco
dc.description.fil
Fil: Gasparoto, Thais Helena. Universidad de São Paulo. Faculdade de Odontologia de Bauru. Departamento de Ciencias Biológicas; Brasil
dc.description.fil
Fil: Ervolino de Oliveira, Carine. Universidad de São Paulo. Faculdade de Odontologia de Bauru. Departamento de Ciencias Biológicas; Brasil
dc.description.fil
Fil: Thomazini de Freitas, Luisa. Universidad de São Paulo. Faculdade de Odontologia de Bauru. Departamento de Ciencias Biológicas; Brasil
dc.description.fil
Fil: Ramos Pinheiro, Claudia. Universidad de São Paulo. Faculdade de Odontologia de Bauru. Departamento de Ciencias Biológicas; Brasil
dc.description.fil
Fil: Issa Hori, Juliana. University of São Paulo. Faculdade de Medicina de Ribeirão Preto; Brasil
dc.description.fil
Fil: Pompermaier Garlet, Gustavo. Universidad de São Paulo. Faculdade de Odontologia de Bauru. Departamento de Ciencias Biológicas; Brasil
dc.description.fil
Fil: Cavassani, Karen Angélica. University Of Michigan; Estados Unidos
dc.description.fil
Fil: Schillaci, Roxana. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina
dc.description.fil
Fil: Santana Da Silva, Joao. University of São Paulo. Faculdade de Medicina de Ribeirão Preto; Brasil
dc.description.fil
Fil: Simmões Zamboni, Darío. University of São Paulo. Faculdade de Medicina de Ribeirão Preto; Brasil
dc.description.fil
Fil: Campanelli, Ana Paula. Universidad de São Paulo. Faculdade de Odontologia de Bauru. Departamento de Ciencias Biológicas; Brasil
dc.journal.title
Plos One
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pone.0107170
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4182037/
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/pmid/25268644
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1371/journal.pone.0107170
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0107170
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/pmid/PMC4182037
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