Artículo
Photodynamic inactivation of multiresistant bacteria (KPC) using zinc(II)phthalocyanines
Fecha de publicación:
09/2017
Editorial:
Elsevier
Revista:
Biorganic and Medicinal Chemistry Letters
ISSN:
0960-894X
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
The worldwide increase in antibiotic resistance has led to search of alternatives anti-microbial therapies such as photodynamic inactivation. The aim of this paper was to evaluate the photodynamic activity in vitro of a neutral and two cationic Zn phthalocyanines. Their photokilling activity was tested on Escherichia coli ATCC 25922 and Klebsiella pneumoniae Carbapenemase (KPC)-producing. After treating bacteria with phthalocyanines, the cultures were irradiated with white light. As a result, the bacteria were inactivated in presence of cationic phthalocyanines. The photoinactivation was dependent of the irradiation time and phthalocyanine concentration. The most effective photosensitizer on KPC-producing was Zinc(II)tetramethyltetrapyridino[2,3-b:2′,3′-g:2″,3″-l:2‴,3‴-q]porphyrazinium methylsulfate (ZnTM2,3PyPz). After irradiation using the water soluble ZnTM2,3PyPz (3 μM) the viability of KPC (30 min of irradiation) and E. coli (10 min of irradiation) decreased ≈99.995%.
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Articulos(INFIQC)
Articulos de INST.DE INVESTIGACIONES EN FISICO- QUIMICA DE CORDOBA
Articulos de INST.DE INVESTIGACIONES EN FISICO- QUIMICA DE CORDOBA
Citación
Miretti, Mariana; Clementi, Romina; Tempesti, Tomas Cristian; Baumgartner, Maria Teresa del V.; Photodynamic inactivation of multiresistant bacteria (KPC) using zinc(II)phthalocyanines; Elsevier; Biorganic and Medicinal Chemistry Letters; 27; 18; 9-2017; 4341-4344
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