Repositorio Institucional
Repositorio Institucional
CONICET Digital
  • Inicio
  • EXPLORAR
    • AUTORES
    • DISCIPLINAS
    • COMUNIDADES
  • Estadísticas
  • Novedades
    • Noticias
    • Boletines
  • Ayuda
    • General
    • Datos de investigación
  • Acerca de
    • CONICET Digital
    • Equipo
    • Red Federal
  • Contacto
JavaScript is disabled for your browser. Some features of this site may not work without it.
  • INFORMACIÓN GENERAL
  • RESUMEN
  • ESTADISTICAS
 
Artículo

Total synchronous fluorescence spectroscopic data modeled with firstand second-order algorithms for the determination of doxorubicin in human plasma

Schenone, Agustina VioletaIcon ; Culzoni, Maria JuliaIcon ; Campiglia, Andres D.; Goicoechea, Hector CasimiroIcon
Fecha de publicación: 08/2013
Editorial: Springer Heidelberg
Revista: Analytical and Bioanalytical Chemistry
ISSN: 1618-2642
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Química Analítica

Resumen

In this work, we present the development of a method for the determination of doxorubicin in plasma samples in the presence of an unexpected component (riboflavin) by using total synchronous fluorescence spectroscopic data matrices. To the best of our knowledge, this is the first time that the second-order advantage is obtained with this kind of data. Two strategies including unfolding the data and: (a) processing with multivariate curve resolution coupled to alternating least-squares as first-order data or (b) processing with unfolded partial least-squares and exploiting the second order advantage by the residual bilinearization procedure were considered. The calibration set was built with human plasma samples spiked with doxorubicin, while the validation set was prepared with human plasma samples spiked with both doxorubicin and riboflavin, a drug whose spectrum highly overlaps with the one corresponding to doxorubicin. Both methodologies reached good indicators of accuracy: recoveries of ca. 100 ± 8 % and REP of ca. 5 %; and precision: coefficient of variations between 7 and 9 %.
Palabras clave: Total Synchronous Fluorescence Spectroscopy , Mcr-Als , U-Pls/Rbl , Doxorubicin
Ver el registro completo
 
Archivos asociados
Tamaño: 469.1Kb
Formato: PDF
.
Solicitar
Licencia
info:eu-repo/semantics/restrictedAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/6426
URL: http://link.springer.com/article/10.1007%2Fs00216-013-7261-y
DOI: http://dx.doi.org/10.1007/s00216-013-7261-y
Colecciones
Articulos(CCT - SANTA FE)
Articulos de CTRO.CIENTIFICO TECNOL.CONICET - SANTA FE
Citación
Schenone, Agustina Violeta; Culzoni, Maria Julia; Campiglia, Andres D.; Goicoechea, Hector Casimiro; Total synchronous fluorescence spectroscopic data modeled with firstand second-order algorithms for the determination of doxorubicin in human plasma; Springer Heidelberg; Analytical and Bioanalytical Chemistry; 405; 26; 8-2013; 8515-8523
Compartir
Altmétricas
 

Enviar por e-mail
Separar cada destinatario (hasta 5) con punto y coma.
  • Facebook
  • X Conicet Digital
  • Instagram
  • YouTube
  • Sound Cloud
  • LinkedIn

Los contenidos del CONICET están licenciados bajo Creative Commons Reconocimiento 2.5 Argentina License

https://www.conicet.gov.ar/ - CONICET

Inicio

Explorar

  • Autores
  • Disciplinas
  • Comunidades

Estadísticas

Novedades

  • Noticias
  • Boletines

Ayuda

Acerca de

  • CONICET Digital
  • Equipo
  • Red Federal

Contacto

Godoy Cruz 2290 (C1425FQB) CABA – República Argentina – Tel: +5411 4899-5400 repositorio@conicet.gov.ar
TÉRMINOS Y CONDICIONES