Mostrar el registro sencillo del ítem

dc.contributor.author
Vela Gurovic, Maria Soledad
dc.contributor.author
Díaz Lanza, A. María
dc.contributor.author
Boyano Adánez, María Del Carmen
dc.contributor.author
Estañ Omaña, M. Cristina
dc.contributor.author
Gañán Gõmez, Irene
dc.contributor.author
Murray, Ana Paula
dc.contributor.author
Sancho Lõpez, Pilar
dc.date.available
2018-11-12T15:02:11Z
dc.date.issued
2011-04
dc.identifier.citation
Vela Gurovic, Maria Soledad; Díaz Lanza, A. María; Boyano Adánez, María Del Carmen; Estañ Omaña, M. Cristina; Gañán Gõmez, Irene; et al.; Cytotoxic effects induced by combination of heliantriol B2 and dequalinium against human leukemic cell lines; John Wiley & Sons Ltd; Phytotherapy Research; 25; 4; 4-2011; 603-610
dc.identifier.issn
0951-418X
dc.identifier.uri
http://hdl.handle.net/11336/64229
dc.description.abstract
Natural occurring compounds are considered an important source of antitumoral agents. In the present study, the cytotoxic potential of three pentacyclic triterpenes isolated from Chuquiraga erinacea (Asteraceae), against the human leukemic cell lines NB4 and K562 was assessed. Heliantriol B2 (HB2) showed the highest cytotoxic activity after 24 h treatment showing IC 50 values of 1.98 ± 0.12 μm and 3.52 ± 0.14 μm for NB4 and K562 cells, respectively. This activity was higher than that of the reference compound dequalinium (DQA). Apoptosis and necrosis induced by HB2 in both NB4 and K562 cell lines were analysed by Annexin V/PI labeling. Mitochondrial alterations including reactive oxygen species (ROS) production and mitochondrial transmembrane potential (Δψm) were also tested. The results demonstrated that HB2 induced cell death by apoptosis and necrosis and showed enhanced cytotoxic effects in combination with DQA. Besides, HB2 induced ROS overproduction in NB4 cells and a slight decrease of Δψm. Consequently, our findings prompt further studies on the HB2 mechanism of action and its selectivity to tumor cells in order to assess the potential of HB2 as an agent for cancer treatment. Copyright © 2010 John Wiley & Sons, Ltd.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
John Wiley & Sons Ltd
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Apoptosis
dc.subject
Dequalinium
dc.subject
Heliantriol B2
dc.subject
K562 Cell Line
dc.subject
Leukemia
dc.subject
Nb4 Cell Line
dc.subject.classification
Otras Ciencias Químicas
dc.subject.classification
Ciencias Químicas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.title
Cytotoxic effects induced by combination of heliantriol B2 and dequalinium against human leukemic cell lines
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-11-05T19:06:03Z
dc.journal.volume
25
dc.journal.number
4
dc.journal.pagination
603-610
dc.journal.pais
Reino Unido
dc.journal.ciudad
Londres
dc.description.fil
Fil: Vela Gurovic, Maria Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentina. Universidad de Alcalá; España
dc.description.fil
Fil: Díaz Lanza, A. María. Universidad de Alcalá; España
dc.description.fil
Fil: Boyano Adánez, María Del Carmen. Universidad de Alcalá; España
dc.description.fil
Fil: Estañ Omaña, M. Cristina. Universidad de Alcalá; España
dc.description.fil
Fil: Gañán Gõmez, Irene. Universidad de Alcalá; España
dc.description.fil
Fil: Murray, Ana Paula. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentina
dc.description.fil
Fil: Sancho Lõpez, Pilar. Universidad de Alcalá; España
dc.journal.title
Phytotherapy Research
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.1002/ptr.3310
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1002/ptr.3310


Archivos asociados

Documento no disponible

Comunidades y colecciones

Mostrar el registro sencillo del ítem