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dc.contributor.author
Ferreira, M. R.
dc.contributor.author
Chicco, Adriana Graciela
dc.contributor.author
Lombardo, Y. B.
dc.date.available
2016-07-07T20:43:24Z
dc.date.issued
2013-05
dc.identifier.citation
Ferreira, M. R.; Chicco, Adriana Graciela; Lombardo, Y. B.; Dietary fish oilnormalized glucose-stimulated insulin secretion in isolated pancreatic islets of dyslipemic rats through mechanisms involving glucose phosphorylation ,peroxisome proliferator-activated receptor γ and uncoupling protein2; Elsevier; Prostaglandins Leukotrienes And Essential Fatty Acids; 89; 1; 5-2013; 31-38
dc.identifier.issn
0952-3278
dc.identifier.uri
http://hdl.handle.net/11336/6412
dc.description.abstract
This study evaluates some possible mechanisms behind the beneficial effects of dietary fish oil (FO) on β cell dysfunction in rats fed a sucrose-rich diet (SRD). Rats were fed a SRD for 6 months. Thereafter, half the rats received a SRD in which corn oil was partially replaced by FO up to 8 months. The other half continued consuming the SRD up to 8 months. A control group was fed a control diet throughout the experimental period. In isolated islets of SRD-fed rats dietary FO normalized the reduced glucose phosphorylation, the altered glucose oxidation, the triglyceride content, the increased protein mass levels of peroxisome proliferator-activated receptor γ (PPARγ) and uncoupling protein 2 without changes in GLUT2 and PPARα. These finding suggest that the changes mentioned above could be involved in the normalization of the altered glucose-stimulated insulin secretion pattern in this nutritional model of dyslipidemia and insulin resistance.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject
Aceite de Pescado
dc.subject
Dislipidemia
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Secrecion De Insulina Inducida por Glucosa
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Ucp2 Ppars
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Nutrición, Dietética
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Ciencias de la Salud
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Dietary fish oilnormalized glucose-stimulated insulin secretion in isolated pancreatic islets of dyslipemic rats through mechanisms involving glucose phosphorylation ,peroxisome proliferator-activated receptor γ and uncoupling protein2
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2016-07-06T15:45:21Z
dc.journal.volume
89
dc.journal.number
1
dc.journal.pagination
31-38
dc.journal.pais
Países Bajos
dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Ferreira, M. R.. Universidad Nacional del Litoral. Facultad de Bioquimica y Ciencias Biologicas. Departamento de Cs.biologicas; Argentina
dc.description.fil
Fil: Chicco, Adriana Graciela. Universidad Nacional del Litoral. Facultad de Bioquimica y Ciencias Biologicas. Departamento de Cs.biologicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Santa Fe; Argentina
dc.description.fil
Fil: Lombardo, Y. B.. Universidad Nacional del Litoral. Facultad de Bioquimica y Ciencias Biologicas. Departamento de Cs.biologicas; Argentina
dc.journal.title
Prostaglandins Leukotrienes And Essential Fatty Acids
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0952327813000963
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.plefa.2013.04.006
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.plefa.2013.04.006
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