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dc.contributor.author
Durando, Milena de Lourdes
dc.contributor.author
Cocito, Laura
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Rodriguez, Horacio Adolfo
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Varayoud, Jorgelina Guadalupe
dc.contributor.author
Ramos, Jorge G.
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Luque, Enrique Hugo
dc.contributor.author
Muñoz de Toro, Mónica
dc.date.available
2016-07-07T20:21:11Z
dc.date.issued
2013-06
dc.identifier.citation
Durando, Milena de Lourdes; Cocito, Laura; Rodriguez, Horacio Adolfo; Varayoud, Jorgelina Guadalupe; Ramos, Jorge G. ; et al.; Neonatal expression of amh, sox9 and sf-1 mRNA in Caiman latirostris and effects of in ovo exposure to endocrine disrupting chemicals; Elsevier; General and Comparative Endocrinology; 191; 6-2013; 31-38
dc.identifier.issn
0016-6480
dc.identifier.uri
http://hdl.handle.net/11336/6404
dc.description.abstract
Caiman latirostris is one of the reptilian species that exhibits temperature-dependent sex determination (TSD). In addition, male-to-female sex reversal after in ovo estrogen/xenoestrogen exposure was demonstrated, called as hormone-dependent sex determination (HSD). The amh, sox9 and sf-1 genes are involved in sex determination, sex differentiation, and steroidogenesis. The aims of this study were: a) to establish the expression patterns of amh, sox9 and sf-1 mRNA in the gonad-adrenal-mesonephros (GAM) complexes of neonatal TSD-male and TSD-female caimans, b) to compare the expression of these genes between TSD-females versus HSD-females (born from E2-exposed eggs incubated at the male-producing temperature) and c) to evaluate whether these genes are affected by in ovo exposure to 17b-estradiol (E2) and two endocrine disrupting chemicals (bisphenol A (BPA) or endosulfan (END)). The mRNA expression of amh, sox9 and sf-1 in GAM complexes from TSD-males and TSD-females, and from HSD-females were quantitatively compared by RT-PCR. In neonatal caimans, we demonstrated a sexually dimorphic pattern of amh and sox9 mRNA expression, with a higher expression in TSD-male than in TSD-female GAM. sf-1 mRNA did not differ between TSD-males and TSD-females. Between females, HSD-females exhibited a higher expression of sox9 than TSD-females. Increased mRNA expression of sex-determining genes was observed in the GAM of neonatal males, in ovo exposed to END. No changes were observed after BPA exposure, and E2 decreased the sox9 but increased the sf-1 mRNA expression. These results provide a new insight into the mechanisms of gonadal histo-functional alterations in caimans exposed to contaminated environments.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject
Caiman Latirostris
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Development
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Endocrinology
dc.subject
Sox
dc.subject.classification
Endocrinología y Metabolismo
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Medicina Clínica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Neonatal expression of amh, sox9 and sf-1 mRNA in Caiman latirostris and effects of in ovo exposure to endocrine disrupting chemicals
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2016-07-06T15:47:02Z
dc.journal.volume
191
dc.journal.pagination
31-38
dc.journal.pais
Países Bajos
dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Durando, Milena de Lourdes. Universidad Nacional del Litoral. Facultad de Bioquimica y Ciencias Biologicas. Departamento de Fisiologia. Laboratorio de Endocrinologia y Tumores Hormonodependientes; Argentina
dc.description.fil
Fil: Cocito, Laura. Universidad Nacional del Litoral. Facultad de Bioquimica y Ciencias Biologicas. Departamento de Fisiologia. Laboratorio de Endocrinologia y Tumores Hormonodependientes; Argentina
dc.description.fil
Fil: Rodriguez, Horacio Adolfo. Universidad Nacional del Litoral. Facultad de Bioquimica y Ciencias Biologicas. Departamento de Fisiologia. Laboratorio de Endocrinologia y Tumores Hormonodependientes; Argentina
dc.description.fil
Fil: Varayoud, Jorgelina Guadalupe. Universidad Nacional del Litoral. Facultad de Bioquimica y Ciencias Biologicas. Departamento de Fisiologia. Laboratorio de Endocrinologia y Tumores Hormonodependientes; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Santa Fe; Argentina
dc.description.fil
Fil: Ramos, Jorge G. . Universidad Nacional del Litoral. Facultad de Bioquimica y Ciencias Biologicas. Departamento de Fisiologia. Laboratorio de Endocrinologia y Tumores Hormonodependientes; Argentina
dc.description.fil
Fil: Luque, Enrique Hugo. Universidad Nacional del Litoral. Facultad de Bioquimica y Ciencias Biologicas. Departamento de Fisiologia. Laboratorio de Endocrinologia y Tumores Hormonodependientes; Argentina
dc.description.fil
Fil: Muñoz de Toro, Mónica. Universidad Nacional del Litoral. Facultad de Bioquimica y Ciencias Biologicas. Departamento de Fisiologia. Laboratorio de Endocrinologia y Tumores Hormonodependientes; Argentina
dc.journal.title
General and Comparative Endocrinology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0016648013002359
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.ygcen.2013.05.013
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.ygcen.2013.05.013
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