Artículo
The effects of ω−6 and ω−3 fatty-acids on early stages of mice DMBA submandibular glands tumorigenesis
Scherma, Maria Eugenia; Madzzuduli, G.; Silva, R.A.; Garay, María Isabel
; Repossi Marquez, Pablo Gaston
; Brunotto, Mabel Noemí; Pasqualini, María Eugenia
Fecha de publicación:
10/2017
Editorial:
Elsevier
Revista:
Prostaglandins Leukotrienes and Essential Fatty Acids
ISSN:
0952-3278
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
The aim of this work was: to assess the impact of diets enriched in polyunsaturated fatty acids ω−3 and ω−6 families on the lipid profile of cell membrane and their effect on cycle regulation and apoptosis, evaluated by TP53 and Ki-67 expression in 9,10-dimethyl-1,2-benzanthracene (DMBA) induced tumor development in submandibular glands (SMG) in murine models. To generate tumorigenic changes, SMG mice in the experimental group were injected with 50 μl of 0.5% of DMBA. Both control (no DMBA) and experimental groups of BALB/c mice were fed with: chia oil (ChO), rich in ω−3 fatty acid; corn oil (CO), rich in ω−6/ω−3 fatty acid; and safflower (SO) oil, rich in ω−6fatty acid. Results demonstrate novel differential effects of ω−3 and ω−6 PUFAs on the regulation of early tumorigenesis events in murine SMG injected with DMBA. This knowledge may help to develop chemoprotective treatments, therapeutic agents and health promotion and prevention activities in humans.
Palabras clave:
Apoptosis
,
Cell Proliferation
,
Dmba
,
Eicosanoids
,
Fatty Acids
,
Tumorigenesis
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Identificadores
Colecciones
Articulos(INICSA)
Articulos de INSTITUTO DE INVESTIGACIONES EN CIENCIAS DE LA SALUD
Articulos de INSTITUTO DE INVESTIGACIONES EN CIENCIAS DE LA SALUD
Citación
Scherma, Maria Eugenia; Madzzuduli, G.; Silva, R.A.; Garay, María Isabel; Repossi Marquez, Pablo Gaston; et al.; The effects of ω−6 and ω−3 fatty-acids on early stages of mice DMBA submandibular glands tumorigenesis; Elsevier; Prostaglandins Leukotrienes and Essential Fatty Acids; 125; 10-2017; 48-55
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