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dc.contributor.author
Li, Chun Shun
dc.contributor.author
Sarotti, Ariel Marcelo
dc.contributor.author
Huang, Peng
dc.contributor.author
Dang, Uyen T.
dc.contributor.author
Hurdle, Julian G.
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Kondratyuk, Tamara P.
dc.contributor.author
Pezzuto, J. M.
dc.contributor.author
Turkson, James Turkson
dc.contributor.author
Cao, Shugeng
dc.date.available
2018-11-07T15:56:24Z
dc.date.issued
2017-12
dc.identifier.citation
Li, Chun Shun; Sarotti, Ariel Marcelo; Huang, Peng; Dang, Uyen T.; Hurdle, Julian G.; et al.; NF-κB inhibitors, unique γ-pyranol-γ-lactams with sulfide and sulfoxide moieties from Hawaiian plant Lycopodiella cernua derived fungus Paraphaeosphaeria neglecta FT462; Nature Publishing Group; Scientific Reports; 7; 1; 12-2017; 1-10
dc.identifier.issn
2045-2322
dc.identifier.uri
http://hdl.handle.net/11336/63876
dc.description.abstract
LC-UV/MS-based metabolomic analysis of the Hawaiian endophytic fungus Paraphaeosphaeria neglecta FT462 led to the identification of four unique mercaptolactated γ-pyranol-γ-lactams, paraphaeosphaerides E-H (1-4) together with one γ-lactone (5) and the methyl ester of compound 2 (11). The structures of the new compounds (1-5 and 11) were elucidated through the analysis of HRMS and NMR spectroscopic data. The absolute configuration was determined by chemical reactions with sodium borohydride, hydrogen peroxide, α-methoxy-α-(trifluoromethyl)phenylacetyl chlorides (Mosher reagents), and DP4 + NMR calculations. All the compounds were tested against STAT3, A2780 and A2780cisR cancer cell lines, E. coli JW2496, and NF-κB. Compounds 1 and 3 strongly inhibited NF-κB with IC50 values of 7.1 and 1.5 μM, respectively.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Nature Publishing Group
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Nf-Kb Inhibitors
dc.subject
Pyranol Lactams
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Dp4+
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Otras Ciencias Químicas
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Ciencias Químicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
NF-κB inhibitors, unique γ-pyranol-γ-lactams with sulfide and sulfoxide moieties from Hawaiian plant Lycopodiella cernua derived fungus Paraphaeosphaeria neglecta FT462
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-10-23T16:34:09Z
dc.journal.volume
7
dc.journal.number
1
dc.journal.pagination
1-10
dc.journal.pais
Reino Unido
dc.description.fil
Fil: Li, Chun Shun. University of Hawai'i at Hilo; Estados Unidos
dc.description.fil
Fil: Sarotti, Ariel Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; Argentina
dc.description.fil
Fil: Huang, Peng. University of Hawai'i at Hilo; Estados Unidos. Anhui University of Chinese Medicine; China
dc.description.fil
Fil: Dang, Uyen T.. Texas A&M University; Estados Unidos
dc.description.fil
Fil: Hurdle, Julian G.. Texas A&M University; Estados Unidos
dc.description.fil
Fil: Kondratyuk, Tamara P.. University of Hawai'i at Hilo; Estados Unidos
dc.description.fil
Fil: Pezzuto, J. M.. University of Hawai'i at Hilo; Estados Unidos. Arnold & Marie Schwartz College of Pharmacy and Health Sciences; Estados Unidos
dc.description.fil
Fil: Turkson, James Turkson. University of Hawai'i; Estados Unidos
dc.description.fil
Fil: Cao, Shugeng. University of Hawai'i at Hilo; Estados Unidos
dc.journal.title
Scientific Reports
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1038/s41598-017-10537-1
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.nature.com/articles/s41598-017-10537-1
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