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dc.contributor.author
Comin, Romina
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dc.contributor.author
Cid, Mariana Paula
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dc.contributor.author
Grinschpun, Luciano
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dc.contributor.author
Oldani, Carlos Rodolfo
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dc.contributor.author
Salvatierra, Nancy Alicia
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dc.date.available
2018-11-07T15:46:38Z
dc.date.issued
2017-04
dc.identifier.citation
Comin, Romina; Cid, Mariana Paula; Grinschpun, Luciano; Oldani, Carlos Rodolfo; Salvatierra, Nancy Alicia; Titanium-hydroxyapatite composites sintered at low temperature for tissue engineering: In vitro cell support and biocompatibility; Wichtig Publishing Srl; Journal of Applied Biomaterials and Functional Materials; 15; 2; 4-2017; e176-e183
dc.identifier.issn
2280-8000
dc.identifier.uri
http://hdl.handle.net/11336/63872
dc.description.abstract
In clinical orthopedics, a critical problem is the bone tissue loss produced by a disease or injury. The use of composites from titanium and hydroxyapatite for biomedical applications has increased due to the resulting advantageous combination of hydroxyapatite bioactivity and favorable mechanical properties of titanium. Powder metallurgy is a simple and lower-cost method that uses powder from titanium and hydroxyapatite to obtain composites having hydroxyapatite phases in a metallic matrix. However, this method has certain limitations arising from thermal decomposition of hydroxyapatite in the titanium-hydroxyapatite system above 800°C. We obtained a composite from titanium and bovine hydroxyapatite powders sintered at 800°C and evaluated its bioactivity and cytocompatibility according to the ISO 10993 standard. Methods: Surface analysis and bioactivity of the composite was evaluated by X-ray diffraction and SEM. MTT assay was carried out to assess cytotoxicity on Vero and NIH3T3 cells. Cell morphology and cell adhesion on the composite surface were analyzed using fluorescence and SEM. Results: We obtained a porous composite with hydroxyapatite particles well integrated in titanium matrix which presented excellent bioactivity. Our data did not reveal any toxicity of titanium-hydroxyapatite composite on Vero or NIH3T3 cells. Moreover, extracts from composite did not affect cell morphology or density. Finally, NIH3T3 cells were capable of adhering to and proliferating on the composite surface. Conclusions: The composite obtained displayed promising biomedical applications through the simple method of powder metallurgy. Additionally, these findings provide an in vitro proof for adequate biocompatibility of titanium-hydroxyapatite composite sintered at 800°C.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Wichtig Publishing Srl
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Biocompatibility
dc.subject
Composite
dc.subject
Hydroxyapatite
dc.subject
Powder Metallurgy
dc.subject
Titanium
dc.title
Titanium-hydroxyapatite composites sintered at low temperature for tissue engineering: In vitro cell support and biocompatibility
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-10-22T20:19:47Z
dc.journal.volume
15
dc.journal.number
2
dc.journal.pagination
e176-e183
dc.journal.pais
Reino Unido
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dc.description.fil
Fil: Comin, Romina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Biológicas y Tecnológicas. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Instituto de Investigaciones Biológicas y Tecnológicas; Argentina
dc.description.fil
Fil: Cid, Mariana Paula. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Biológicas y Tecnológicas. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Instituto de Investigaciones Biológicas y Tecnológicas; Argentina
dc.description.fil
Fil: Grinschpun, Luciano. Universidad Nacional de Córdoba. Facultad de Cs.exactas Físicas y Naturales. Departamento de Materiales y Tecnología; Argentina
dc.description.fil
Fil: Oldani, Carlos Rodolfo. Universidad Nacional de Córdoba. Facultad de Cs.exactas Físicas y Naturales. Departamento de Materiales y Tecnología; Argentina
dc.description.fil
Fil: Salvatierra, Nancy Alicia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Biológicas y Tecnológicas. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Instituto de Investigaciones Biológicas y Tecnológicas; Argentina
dc.journal.title
Journal of Applied Biomaterials and Functional Materials
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://journals.sagepub.com/doi/10.5301/jabfm.5000340
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.5301/jabfm.5000340
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