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dc.contributor.author
Sookoian, Silvia Cristina
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Pirola, Carlos José
dc.date.available
2018-11-06T18:11:19Z
dc.date.issued
2017-03
dc.identifier.citation
Sookoian, Silvia Cristina; Pirola, Carlos José; Genetic predisposition in nonalcoholic fatty liver disease; Korean Association for the Study of the Liver; Clinical and Molecular Hepatology; 23; 1; 3-2017; 1-12
dc.identifier.issn
2287-285X
dc.identifier.uri
http://hdl.handle.net/11336/63784
dc.description.abstract
Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease whose prevalence has reached global epidemic proportions. Although the disease is relatively benign in the early stages, when severe clinical forms, including nonalcoholic steatohepatitis (NASH), cirrhosis and even hepatocellular carcinoma, occur, they result in worsening the long-term prognosis. A growing body of evidence indicates that NAFLD develops from a complex process in which many factors, including genetic susceptibility and environmental insults, are involved. In this review, we focused on the genetic component of NAFLD, with special emphasis on the role of genetics in the disease pathogenesis and natural history.Insights into the topic of the genetic susceptibility in lean individuals with NAFLD and the potential use of genetic tests in identifying individuals at risk are also discussed. (Clin Mol Hepatol 2017;23:1-12).
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application/pdf
dc.language.iso
eng
dc.publisher
Korean Association for the Study of the Liver
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Genetics
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Nafld
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Review
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Epigenetics
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Mirnas
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Nash
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Alcoholic Liver Disease
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Gene Variants
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Pnpla3
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Tm6sf2
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Genética Humana
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
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Gastroenterología y Hepatología
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Medicina Clínica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Genetic predisposition in nonalcoholic fatty liver disease
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-10-23T19:48:41Z
dc.journal.volume
23
dc.journal.number
1
dc.journal.pagination
1-12
dc.journal.pais
Corea del Sur
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Seul
dc.description.fil
Fil: Sookoian, Silvia Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
dc.description.fil
Fil: Pirola, Carlos José. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
dc.journal.title
Clinical and Molecular Hepatology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.3350/cmh.2016.0109
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.e-cmh.org/journal/view.php?doi=10.3350/cmh.2016.0109