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dc.contributor.author
Pautassi, Ricardo Marcos
dc.contributor.author
Suarez, Andrea Beatriz
dc.contributor.author
Hoffmann, Lucas Barbosa
dc.contributor.author
Rueda, André Veloso
dc.contributor.author
Rae, Mariana
dc.contributor.author
Marianno, Priscila
dc.contributor.author
Camarini, Rosana
dc.date.available
2018-11-06T15:49:03Z
dc.date.issued
2017-12-17
dc.identifier.citation
Pautassi, Ricardo Marcos; Suarez, Andrea Beatriz; Hoffmann, Lucas Barbosa; Rueda, André Veloso; Rae, Mariana; et al.; Effects of environmental enrichment upon ethanol-induced conditioned place preference and pre-frontal BDNF levels in adolescent and adult mice; Nature Publishing Group; Scientific Reports; 7; 1; 17-12-2017; 1-12
dc.identifier.issn
2045-2322
dc.identifier.uri
http://hdl.handle.net/11336/63746
dc.description.abstract
Environmental enrichment (EE) provides a non-pharmacological tool to alter drug-induced reward, yet its effects on ethanol-induced reward remain controversial. We analyzed adolescent vs. adult (mice) differences in the influence of EE on ethanol-induced conditioned place preference (CPP). The effects of these treatments on brain-derived neurotrophic factor (BDNF) levels in the prefrontal cortex were examined in a separate group of animals. Ethanol-induced CPP was found in adults, and it was similar in EE and in animals reared under standard housing conditions (SC). Adolescents kept under EE, but not those in SC, exhibited CPP. Among SC, but not among EE, adolescents, BDNF levels were significantly lower in those treated with ethanol than in those given vehicle. These results indicate that, compared to adults, adolescent exhibited reduced sensitivity to ethanol's rewarding effects, yet the youth but not the adults exhibited sensitivity to the promoting effect of EE upon CPP by ethanol. Ethanol significantly reduced BDNF levels in adolescents reared under standard housing conditions, but not in adult mice nor in adolescents given EE housing conditions. The present results add to the plethora of adolescent-specific responses to ethanol or to environmental stimuli that may put the youth at risk for escalation of ethanol intake.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Nature Publishing Group
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Ethanol
dc.subject
Environmental Enrichment
dc.subject
Bdnf
dc.subject
Adolescent
dc.subject.classification
Otras Ciencias Biológicas
dc.subject.classification
Ciencias Biológicas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.title
Effects of environmental enrichment upon ethanol-induced conditioned place preference and pre-frontal BDNF levels in adolescent and adult mice
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-10-22T16:48:27Z
dc.journal.volume
7
dc.journal.number
1
dc.journal.pagination
1-12
dc.journal.pais
Reino Unido
dc.journal.ciudad
Londres
dc.description.fil
Fil: Pautassi, Ricardo Marcos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina. Universidad Nacional de Córdoba. Facultad de Psicología; Argentina
dc.description.fil
Fil: Suarez, Andrea Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
dc.description.fil
Fil: Hoffmann, Lucas Barbosa. Universidade de Sao Paulo; Brasil
dc.description.fil
Fil: Rueda, André Veloso. Universidade de Sao Paulo; Brasil
dc.description.fil
Fil: Rae, Mariana. Universidade de Sao Paulo; Brasil
dc.description.fil
Fil: Marianno, Priscila. Universidade de Sao Paulo; Brasil
dc.description.fil
Fil: Camarini, Rosana. Universidade de Sao Paulo; Brasil
dc.journal.title
Scientific Reports
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.nature.com/articles/s41598-017-08795-0
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.1038/s41598-017-08795-0


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