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dc.contributor.author
Alvarez, Florencia  
dc.contributor.author
Schilardi, Patricia Laura  
dc.contributor.author
Fernandez Lorenzo, Monica Alicia  
dc.date.available
2016-07-05T18:07:03Z  
dc.date.issued
2012-01  
dc.identifier.citation
Alvarez, Florencia; Schilardi, Patricia Laura; Fernandez Lorenzo, Monica Alicia; Reduction of the "burst release" of copper ions from copper-based Intrauterine Devices (IUD) by organic inhibitors; Elsevier; Contraception; 85; 1; 1-2012; 91–98  
dc.identifier.issn
0010-7824  
dc.identifier.uri
http://hdl.handle.net/11336/6364  
dc.description.abstract
The copper intrauterine device is a contraceptive method that is based on the release of copper ions from a copper wire. Immediately after insertion, the dissolution of copper in the uterine fluid is markedly higher ("burst release") than that necessary for contraception action, leading to a variety of harmful effects. STUDY DESIGN: Pretreatments with organic compounds [thiourea (TU) and purine (PU), 10(-4)-10(-2) M concentration range, 1- and 3-h immersion times] were tested. The dissolution of copper with and without pretreatments in TU and PU solutions was analyzed by conventional electrochemical techniques and surface analysis. RESULTS: Pretreatments in PU solutions reduced the initial corrosion rate of copper in simulated uterine solutions, with inhibitory efficiencies that depend on the PU concentration and on the immersion time assayed. Inhibitory efficiency values higher than 98% for pretreatments with ≥10(-3) M PU were found. Conversely, after TU pretreatments, a high copper release was measured. CONCLUSIONS: It was concluded that 10(-3) M PU pretreatment is a promising strategy able to reduce the "burst release" of copper and to ensure contraceptive action.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Elsevier  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/  
dc.subject
Iud  
dc.subject
Metal Ion Release  
dc.subject
Corrosion  
dc.subject
Adsorption  
dc.subject.classification
Química Orgánica  
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Ciencias Químicas  
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CIENCIAS NATURALES Y EXACTAS  
dc.title
Reduction of the "burst release" of copper ions from copper-based Intrauterine Devices (IUD) by organic inhibitors  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2016-05-10T14:31:24Z  
dc.journal.volume
85  
dc.journal.number
1  
dc.journal.pagination
91–98  
dc.journal.pais
Países Bajos  
dc.journal.ciudad
Amsterdam  
dc.description.fil
Fil: Alvarez, Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico la Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentina  
dc.description.fil
Fil: Schilardi, Patricia Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico la Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentina  
dc.description.fil
Fil: Fernandez Lorenzo, Monica Alicia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico la Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentina. Universidad Nacional de La Plata; Argentina  
dc.journal.title
Contraception  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.contraception.2011.05.011  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.contraception.2011.05.011  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/pmid/22067791  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0010782411002447