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Artículo

Evaluation of sodium arsenite exposure on reproductive competence in pregnant and postlactational dams and their offspring

Bourguignon, NadiaIcon ; Bonaventura, Maria MartaIcon ; Rodríguez, Diego; Bizzozzero Hiriart, MarianneIcon ; Ventura, ClaraIcon ; Nuñez, Mariel; Lux, Victoria Adela R.Icon ; Libertun, CarlosIcon
Fecha de publicación: 04/2017
Editorial: Pergamon-Elsevier Science Ltd
Revista: Reproductive Toxicology
ISSN: 0890-6238
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Toxicología

Resumen

We investigated arsenite exposure on the reproductive axis of dams (during pregnancy and at cyclicity resumption) and their offspring. Pregnant rats were exposed to 5 (A5) or 50 ppm (A50) of sodium arsenite in drinking water from gestational day 1 (GD1) until sacrifice at GD18 or two months postpartum. Offspring were exposed to the same treatment as their mothers from weaning to adulthood. A50-pregnant rats gained less weight, showed increased testosterone and estradiol but pregnancy was unaffected. After lactation, arsenic-exposed dams presented compromised cyclicity, decreased estradiol, increased follicle-stimulating hormone (FSH), less preovulatory follicles and presence of ovarian cysts, suggesting impaired reproduction. A50-offspring presented lower body weight; A50-female-offspring showed elevated gonadotropin releasing hormone (GnRH), FSH and testosterone, while A50-males showed diminished GnRH/FSH, but normal testosterone. We conclude that arsenite at the present exposure levels did not compromise pregnancy outcome while it negatively affected reproductive physiology in postpartum dams and their offspring.
Palabras clave: Hormones , Offspring , Oxidative Stress , Postlactational Estrous Cycles , Pregnancy , Sodium Arsenite , Rats , Arsenic
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/63596
URL: https://www.sciencedirect.com/science/article/pii/S0890623817300072
DOI: http://dx.doi.org/10.1016/j.reprotox.2017.01.002
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Articulos(IBYME)
Articulos de INST.DE BIOLOGIA Y MEDICINA EXPERIMENTAL (I)
Citación
Bourguignon, Nadia; Bonaventura, Maria Marta; Rodríguez, Diego; Bizzozzero Hiriart, Marianne; Ventura, Clara; et al.; Evaluation of sodium arsenite exposure on reproductive competence in pregnant and postlactational dams and their offspring; Pergamon-Elsevier Science Ltd; Reproductive Toxicology; 69; 4-2017; 1-12
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