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dc.contributor.author
Gallegos, Cristina Eugenia
dc.contributor.author
Michelin, Severino
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Baffa Trasci, Sofía
dc.contributor.author
Aballay Lobos, Elizabeth
dc.contributor.author
Dubner, Diana
dc.contributor.author
Carosella, Edgardo D.
dc.date.available
2016-07-05T14:21:33Z
dc.date.issued
2014-02
dc.identifier.citation
Gallegos, Cristina Eugenia; Michelin, Severino; Baffa Trasci, Sofía; Aballay Lobos, Elizabeth; Dubner, Diana; et al.; HLA-G1 increases the radiosensitivity of human tumoral cells; Elsevier; Cellular Immunology; 287; 2; 2-2014; 106-111
dc.identifier.issn
0008-8749
dc.identifier.uri
http://hdl.handle.net/11336/6356
dc.description.abstract
Different molecules regulate the response of tumoral tissues to ionizing radiation. The objective of this work was to determine if HLA-G1 expression modulates the radiosensitivity of human tumoral cell lines. To this end, human melanoma M8 and human erythroleukemia K562 cell lines, with their correspondent HLA-G1 negative and positive variants, were gamma irradiated and the survival frequency was determined by clonogenic assay. The survival fraction of HLA-G1 expressing cells was around 60% of HLA-G1 negative cells. The generation of acidic vesicular organelles was higher in HLA-G1 positive cells. Apoptosis levels showed statistically significant differences only in K562 cells, whereas the variation in G2/M cycle progression was only significant in M8 cells. In addition, irradiation diminished cell-surface HLA-G1 and increased soluble HLA-G1 levels. Soluble HLA-G1 has no influence on cell survival in any cell line. In summary, we could demonstrate that HLA-G1 confers higher radiosensitivity to HLA-G1 expressing cells.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject
Hla-G1
dc.subject
Ionizing Radiation
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Radiosensitivity
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Tumoral Cells
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Melanoma Cells
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Erythroleukemia Cells
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Biología Celular, Microbiología
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
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Inmunología
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
HLA-G1 increases the radiosensitivity of human tumoral cells
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2016-05-10T14:35:22Z
dc.journal.volume
287
dc.journal.number
2
dc.journal.pagination
106-111
dc.journal.pais
Países Bajos
dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Gallegos, Cristina Eugenia. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnológico Bahia Blanca. Instituto de Ciencias Biologicas y Biomedicas del Sur; Argentina. Universidad Nacional del Sur; Argentina. Autoridad Regulatoria Nuclear; Argentina
dc.description.fil
Fil: Michelin, Severino. Autoridad Regulatoria Nuclear; Argentina
dc.description.fil
Fil: Baffa Trasci, Sofía. Autoridad Regulatoria Nuclear; Argentina
dc.description.fil
Fil: Aballay Lobos, Elizabeth. Autoridad Regulatoria Nuclear; Argentina
dc.description.fil
Fil: Dubner, Diana. Autoridad Regulatoria Nuclear; Argentina
dc.description.fil
Fil: Carosella, Edgardo D.. University Paris Diderot; Francia. Commissariat a l’Energie Atomique et aux Energies Alternatives. Institute of Emerging Diseases and Innovative Therapies. Research Division in Hematology and Immunology; Francia
dc.journal.title
Cellular Immunology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.cellimm.2014.01.005
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.cellimm.2014.01.005
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/pmid/24487034
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0008874914000148
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