Artículo
The Trypanosoma cruzi Surface, a Nanoscale Patchwork Quilt
Mucci, Juan Sebastián
; Lantos, Andrés Bernardo Gabriel
; Buscaglia, Carlos Andres
; Leguizamon, Maria Susana
; Campetella, Oscar Eduardo
Fecha de publicación:
01/02/2017
Editorial:
Cell Press
Revista:
Trends In Parasitology
ISSN:
1471-4922
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
The Trypanosoma cruzi trypomastigote membrane provides a major protective role against mammalian host-derived defense mechanisms while allowing the parasite to interact with different cell types and trigger pathogenesis. This surface has been historically appreciated as a rather unstructured ‘coat’, mainly consisting of a continuous layer of glycolipids and heavily O-glycosylated mucins, occasionally intercalated with different developmentally regulated molecules displaying adhesive and/or enzymatic properties. Recent findings, however, indicate that the trypomastigote membrane is made up of multiple, densely packed and discrete 10–150 nm lipid-driven domains bearing different protein composition; hence resembling a highly organized ‘patchwork quilt’ design. Here, we discuss different aspects underlying the biogenesis, assembly, and dynamics of this cutting-edge fashion outfit, as well as its functional implications.
Palabras clave:
Membrane Domains
,
Membrane Vesicle
,
Mucin
,
Sialic Acids
,
Trans-Sialidase
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Identificadores
Colecciones
Articulos(IIB-INTECH)
Articulos de INST.DE INVEST.BIOTECNOLOGICAS - INSTITUTO TECNOLOGICO CHASCOMUS
Articulos de INST.DE INVEST.BIOTECNOLOGICAS - INSTITUTO TECNOLOGICO CHASCOMUS
Citación
Mucci, Juan Sebastián; Lantos, Andrés Bernardo Gabriel; Buscaglia, Carlos Andres; Leguizamon, Maria Susana; Campetella, Oscar Eduardo; The Trypanosoma cruzi Surface, a Nanoscale Patchwork Quilt; Cell Press; Trends In Parasitology; 33; 2; 1-2-2017; 102-112
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