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dc.contributor.author
Zanin, Juan Pablo
dc.contributor.author
Unsain, Nicolas
dc.contributor.author
Anastasia Gonzalez, Agustin
dc.date.available
2018-11-02T17:56:25Z
dc.date.issued
2017-05
dc.identifier.citation
Zanin, Juan Pablo; Unsain, Nicolas; Anastasia Gonzalez, Agustin; Growth factors and hormones pro-peptides: the unexpected adventures of the BDNF prodomain; Wiley Blackwell Publishing, Inc; Journal of Neurochemistry; 141; 3; 5-2017; 330-340
dc.identifier.issn
0022-3042
dc.identifier.uri
http://hdl.handle.net/11336/63518
dc.description.abstract
Most growth factors and hormones are synthesized as pre-pro-proteins which are processed to the biologically active mature protein. The pre- and prodomains are cleaved from the precursor protein in the secretory pathway or, in some cases, extracellularly. The canonical functions of these prodomains are to assist in folding and stabilization of the mature domain, to direct intra and extracellular localization, to facilitate storage, and to regulate bioavailability of their mature counterpart. Recently, exciting evidence has revealed that prodomains of certain growth factors, after cleaved from the precursor pro-protein, can act as independent active signaling molecules. In this review, we discuss the various classical functions of prodomains, and the biological consequences of these pro-peptides acting as ligands. We will focus our attention on the brain-derived neurotrophic factor prodomain (pBDNF), which has been recently described as a novel secreted ligand influencing neuronal morphology and physiology.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Wiley Blackwell Publishing, Inc
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Active Prodomains
dc.subject
Biosynthetic Pathway
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Pbdnf
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Precursor Cleavage Peptides
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Probdnf
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Val66met Polymorphism
dc.subject.classification
Neurociencias
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Growth factors and hormones pro-peptides: the unexpected adventures of the BDNF prodomain
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-10-22T16:50:09Z
dc.identifier.eissn
1471-4159
dc.journal.volume
141
dc.journal.number
3
dc.journal.pagination
330-340
dc.journal.pais
Reino Unido
dc.journal.ciudad
Londres
dc.conicet.avisoEditorial
This is the peer reviewed version of the following article: Zanin, J. P., Unsain, N. and Anastasia, A. (2017), Growth factors and hormones pro‐peptides: the unexpected adventures of the BDNF prodomain. J. Neurochem., 141: 330-340. doi:10.1111/jnc.13993, which has been published in final form at https://doi.org/10.1111/jnc.13993 . This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
dc.description.fil
Fil: Zanin, Juan Pablo. Rutgers University; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Unsain, Nicolas. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet -Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina.; Argentina
dc.description.fil
Fil: Anastasia Gonzalez, Agustin. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina
dc.journal.title
Journal of Neurochemistry
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1111/jnc.13993
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1111/jnc.13993
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