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dc.contributor.author
Navarro, Lucila
dc.contributor.author
Mogosanu, Diana Elena
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Ceaglio, Natalia Analia
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Luna, Julio Alberto
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Dubruel, Peter
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Rintoul, Ignacio
dc.date.available
2018-11-01T17:18:29Z
dc.date.issued
2017-08
dc.identifier.citation
Navarro, Lucila; Mogosanu, Diana Elena; Ceaglio, Natalia Analia; Luna, Julio Alberto; Dubruel, Peter; et al.; Novel Poly(Diol Sebacate)s as Additives to Modify Paclitaxel Release From Poly(Lactic-co-Glycolic Acid) Thin Films; John Wiley & Sons Inc; Journal of Pharmaceutical Sciences; 106; 8; 8-2017; 2106-2114
dc.identifier.issn
0022-3549
dc.identifier.uri
http://hdl.handle.net/11336/63450
dc.description.abstract
Paclitaxel (PTX) incorporation in poly (lactic acid-co-glycolic acid) (PLGA) matrices produce films with high tensile rigidity and slow release that fail to deliver the required release rate for most biomedical applications such as in drug eluting stents and cancer treatments. To modify and improve this behavior, a set of poly (diol sebacate)s using different aliphatic diol length (1,3propanediol, 1,9-nonanediol and 1,10-decanediol) were synthesized and fully characterized as possible additives. The tensile properties of PLGA blends were evaluated as these materials could be used as drug eluting stent coatings. A significant improvement of mechanical flexibility was observed with 20 % additive content, as it reduced the Young´s Modulus (YM) value and increased the maximum deformation at break. PTX release was studied and correlated with the release of additive from PLGA films. An increase of the initial burst release phase was observed on all the blends when compared to the control films of PLGA. Modulation of PTX release was achieved by altering the hydrophilicity degree of the additive or its percentage content on the blend. This supports the possibility that PTX was partitioned into the additive phase. Cytotoxicity analyses of novel additives were performed on mouse embryonic fibroblasts NIH/3T3.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
John Wiley & Sons Inc
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Coating
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Drug Delivery Systems
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Plga
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Polymer Synthesis
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Polymeric Biomaterials
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Otras Ciencias Químicas
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Ciencias Químicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
Novel Poly(Diol Sebacate)s as Additives to Modify Paclitaxel Release From Poly(Lactic-co-Glycolic Acid) Thin Films
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-10-23T20:52:15Z
dc.journal.volume
106
dc.journal.number
8
dc.journal.pagination
2106-2114
dc.journal.pais
Estados Unidos
dc.description.fil
Fil: Navarro, Lucila. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina
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Fil: Mogosanu, Diana Elena. University of Ghent; Bélgica
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Fil: Ceaglio, Natalia Analia. Universidad Nacional del Litoral; Argentina
dc.description.fil
Fil: Luna, Julio Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina
dc.description.fil
Fil: Dubruel, Peter. University of Ghent; Bélgica
dc.description.fil
Fil: Rintoul, Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina
dc.journal.title
Journal of Pharmaceutical Sciences
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.xphs.2017.05.012
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