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dc.contributor.author Reales, Guillermo
dc.contributor.author Rovaris, Diego L.
dc.contributor.author Jacovas, Vanessa C.
dc.contributor.author Hünemeier, Tábita
dc.contributor.author Sandoval, José R.
dc.contributor.author Salazar Granara, Alcibiades
dc.contributor.author Demarchi, Dario
dc.contributor.author Tarazona Santos, Eduardo
dc.contributor.author Felkl, Aline B.
dc.contributor.author Serafini, Michele A.
dc.contributor.author Salzano, Francisco M.
dc.contributor.author Bisso Machado, Rafael
dc.contributor.author Comas, David
dc.contributor.author Paixão Côrtes, Vanessa R.
dc.contributor.author Bortolini, Maria Catira
dc.date.available 2018-10-30T17:06:43Z
dc.date.issued 2017-07
dc.identifier.citation Reales, Guillermo; Rovaris, Diego L.; Jacovas, Vanessa C.; Hünemeier, Tábita; Sandoval, José R.; et al.; A tale of agriculturalists and hunter-gatherers: Exploring the thrifty genotype hypothesis in native South Americans; Wiley-liss, Div John Wiley & Sons Inc; American Journal Of Physical Anthropology; 163; 3; 7-2017; 591-601
dc.identifier.issn 0002-9483
dc.identifier.uri http://hdl.handle.net/11336/63293
dc.description.abstract Objectives: To determine genetic differences between agriculturalist and hunter-gatherer southern Native American populations for selected metabolism-related markers and to test whether Neel's thrifty genotype hypothesis (TGH) could explain the genetic patterns observed in these populations. Materials and Methods: 375 Native South American individuals from 17 populations were genotyped using six markers (APOE rs429358 and rs7412; APOA2 rs5082; CD36 rs3211883; TCF7L2 rs11196205; and IGF2BP2 rs11705701). Additionally, APOE genotypes from 39 individuals were obtained from the literature. AMOVA, main effects, and gene-gene interaction tests were performed. Results: We observed differences in allele distribution patterns between agriculturalists and hunter-gatherers for some markers. For instance, between-groups component of genetic variance (FCT) for APOE rs429358 showed strong differences in allelic distributions between hunter-gatherers and agriculturalists (p = 0.00196). Gene-gene interaction analysis indicated that the APOE E4/CD36 TT and APOE E4/IGF2BP2 A carrier combinations occur at a higher frequency in hunter-gatherers, but this combination is not replicated in archaic (Neanderthal and Denisovan) and ancient (Anzick, Saqqaq, Ust-Ishim, Mal'ta) hunter-gatherer individuals. Discussion: A complex scenario explains the observed frequencies of the tested markers in hunter-gatherers. Different factors, such as pleotropic alleles, rainforest selective pressures, and population dynamics, may be collectively shaping the observed genetic patterns. We conclude that although TGH seems a plausible hypothesis to explain part of the data, other factors may be important in our tested populations.
dc.format application/pdf
dc.language.iso eng
dc.publisher Wiley-liss, Div John Wiley & Sons Inc
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject ADAPTATION
dc.subject APOE
dc.subject MODE OF SUBSISTENCE
dc.subject PLEIOTROPY
dc.subject.classification Otras Ciencias Biológicas
dc.subject.classification Ciencias Biológicas
dc.subject.classification CIENCIAS NATURALES Y EXACTAS
dc.subject.classification Genética y Herencia
dc.subject.classification Ciencias Biológicas
dc.subject.classification CIENCIAS NATURALES Y EXACTAS
dc.title A tale of agriculturalists and hunter-gatherers: Exploring the thrifty genotype hypothesis in native South Americans
dc.type info:eu-repo/semantics/article
dc.type info:ar-repo/semantics/artículo
dc.type info:eu-repo/semantics/publishedVersion
dc.date.updated 2018-10-19T15:27:50Z
dc.journal.volume 163
dc.journal.number 3
dc.journal.pagination 591-601
dc.journal.pais Estados Unidos
dc.journal.ciudad New Jersey
dc.description.fil Fil: Reales, Guillermo. Universidade Federal do Rio Grande do Sul; Brasil
dc.description.fil Fil: Rovaris, Diego L.. Universidade Federal do Rio Grande do Sul; Brasil
dc.description.fil Fil: Jacovas, Vanessa C.. Universidade Federal do Rio Grande do Sul; Brasil
dc.description.fil Fil: Hünemeier, Tábita. Universidade de Sao Paulo; Brasil
dc.description.fil Fil: Sandoval, José R.. Universidad de San Martín de Porres. Facultad de Medicina Humana; Perú
dc.description.fil Fil: Salazar Granara, Alcibiades. Universidad de San Martín de Porres. Facultad de Medicina Humana; Perú
dc.description.fil Fil: Demarchi, Dario. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Antropología de Córdoba. Universidad Nacional de Córdoba. Facultad de Filosofía y Humanidades. Instituto de Antropología de Córdoba; Argentina
dc.description.fil Fil: Tarazona Santos, Eduardo. Universidade Federal de Minas Gerais; Brasil
dc.description.fil Fil: Felkl, Aline B.. Universidade Federal do Rio Grande do Sul; Brasil
dc.description.fil Fil: Serafini, Michele A.. Universidade Federal do Rio Grande do Sul; Brasil
dc.description.fil Fil: Salzano, Francisco M.. Universidade Federal do Rio Grande do Sul; Brasil
dc.description.fil Fil: Bisso Machado, Rafael. Universidad de la República; Uruguay
dc.description.fil Fil: Comas, David. Universitat Pompeu Fabra; España
dc.description.fil Fil: Paixão Côrtes, Vanessa R.. Universidade Federal da Bahia; Brasil
dc.description.fil Fil: Bortolini, Maria Catira. Universidade Federal do Rio Grande do Sul; Brasil
dc.journal.title American Journal Of Physical Anthropology
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1002/ajpa.23233
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/epdf/10.1002/ajpa.23233
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info:eu-repo/semantics/restrictedAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)