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dc.contributor.author
de Melo, Polyanne N.  
dc.contributor.author
Barbosa, Euzébio G.  
dc.contributor.author
Garnero, Claudia  
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de Caland, Lilia B.  
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Fernandes Pedrosa, Matheus F.  
dc.contributor.author
Longhi, Marcela Raquel  
dc.contributor.author
da Silva Júnior, Arnóbio Antônio  
dc.date.available
2018-10-25T17:11:47Z  
dc.date.issued
2016-11  
dc.identifier.citation
de Melo, Polyanne N.; Barbosa, Euzébio G.; Garnero, Claudia; de Caland, Lilia B.; Fernandes Pedrosa, Matheus F.; et al.; Interaction pathways of specific co-solvents with hydroxypropyl-β-cyclodextrin inclusion complexes with benznidazole in liquid and solid phase; Elsevier Science; Journal of Molecular Liquids; 223; 11-2016; 350-359  
dc.identifier.issn
0167-7322  
dc.identifier.uri
http://hdl.handle.net/11336/63056  
dc.description.abstract
The main purpose of the study was to assess the mechanism whereby the co-solvents triethanolamine (TEA) and 1-methyl-2-pyrrolidone (NMP) interacted with hydroxypropyl-beta-cyclodextrin (HP-β-CD) in ternary associations for improving the solubility and dissolution rate of the insoluble ingredient benznidazole (BNZ). In liquid phase, the solubility diagrams and Job's plot results were further explored by in silico molecular modeling and experimental 1H NMR spectroscopy studies. The structure of the inclusion complexes in the binary and ternary association were established. The competition of NMP with the drug for the HP-β-CD cavity was evidenced, while TEA stabilized the drug-CD interactions, forming ternary complexes. FTIR analysis confirmed distinct intermolecular interactions among the compounds in the different solid dispersions prepared by physical mixture (PM) and spray drying (SD). The co-solvents improved the drug dissolution performance from PM ternary associations due to their enhanced wettability of particles changing the drug-CD interaction. In addition to the SD samples exhibiting spherical particles, the co-solvents increased the crystallinity of drug in the particles and the ternary associations did not reproduce the drug dissolution rate identified in the PM samples. The experimental results proved the importance of the co-solvents to improve the drug dissolution performance from ternary complexes and established the mechanism whereby these substances worked together with the CD in a new and promising raw material. Due to the high temperature, the spray drying was not a suitable method for preparing the specific ternary complexes.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Elsevier Science  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/  
dc.subject
Cyclodextrins  
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Poorly Water-Soluble Drugs  
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Solid Dispersion  
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Solubility  
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Spray Drying  
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Supramolecular Aggregates  
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Nano-materiales  
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Nanotecnología  
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INGENIERÍAS Y TECNOLOGÍAS  
dc.title
Interaction pathways of specific co-solvents with hydroxypropyl-β-cyclodextrin inclusion complexes with benznidazole in liquid and solid phase  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2018-10-23T13:42:51Z  
dc.journal.volume
223  
dc.journal.pagination
350-359  
dc.journal.pais
Países Bajos  
dc.journal.ciudad
Amsterdam  
dc.description.fil
Fil: de Melo, Polyanne N.. Universidade Federal do Rio Grande do Norte; Brasil  
dc.description.fil
Fil: Barbosa, Euzébio G.. Universidade Federal do Rio Grande do Norte; Brasil  
dc.description.fil
Fil: Garnero, Claudia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina  
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Fil: de Caland, Lilia B.. Universidade Federal do Rio Grande do Norte; Brasil  
dc.description.fil
Fil: Fernandes Pedrosa, Matheus F.. Universidade Federal do Rio Grande do Norte; Brasil  
dc.description.fil
Fil: Longhi, Marcela Raquel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina  
dc.description.fil
Fil: da Silva Júnior, Arnóbio Antônio. Universidade Federal do Rio Grande do Norte; Brasil  
dc.journal.title
Journal of Molecular Liquids  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.molliq.2016.08.042  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0167732216305384