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dc.contributor.author
Giuliodori, Mauricio Javier  
dc.contributor.author
Magnasco, M.  
dc.contributor.author
Magnasco, R.P.  
dc.contributor.author
Lacau, Isabel María  
dc.contributor.author
de la Sota, Rodolfo Luzbel  
dc.date.available
2018-10-25T16:08:35Z  
dc.date.issued
2017-05  
dc.identifier.citation
Giuliodori, Mauricio Javier; Magnasco, M.; Magnasco, R.P.; Lacau, Isabel María; de la Sota, Rodolfo Luzbel; Purulent vaginal discharge in grazing dairy cows: Risk factors, reproductive performance, and prostaglandin F2α treatment; American Dairy Science Association; Journal of Dairy Science; 100; 5; 5-2017; 3805-3815  
dc.identifier.issn
0022-0302  
dc.identifier.uri
http://hdl.handle.net/11336/63051  
dc.description.abstract
The objectives of this study were to assess the association of a 4-point scale of vaginal discharge score (VDS) with time to pregnancy to define criteria for a practical case of purulent vaginal discharge (PVD) in dairy cows, to test the risk factors for PVD, and, finally, the effect of a dose of PGF2α on cure and reproductive performance. In experiment 1, grazing Holstein cows (n = 2,414) had their vaginal discharge scored at ∼32 d in milk (DIM) on a 4-point scale, the effect of VDS on the hazard of pregnancy by 300 DIM was then assessed to derive a case definition of PVD. Risk factors for PVD and self-cure were also assessed. In experiment 2, grazing Holstein cows (n = 6,326) from 5 herds were checked for PVD at ∼30 DIM. Cows with PVD were assigned to receive one dose of 500 μg of PGF2α analog (Cloprostenol; Ciclase, Syntex SA, Buenos Aires, Argentina) per cow (odd ear tag number) or to remain untreated (even tag number). Cure was declared if cows presented clear normal vaginal discharge (VDS-0) at visit 2 (∼62 DIM). Data were analyzed with Cox´s regression and mixed logistic models. In experiment 1, cows with VDS ≥1 had lower hazard of pregnancy and longer calving to pregnancy interval than cows with VDS-0. This finding was not affected by the time at which the diagnosis was performed. Therefore, a cow ≥21 DIM and having VDS ≥1 was used to define a case of PVD. The odds of PVD were greater in primiparous cows compared with multiparous, in cows with abnormal calving compared with those with normal calving, and in those losing BCS peripartum. In experiment 2, PGF2α treatment tended to slightly increase the hazard of pregnancy (adjusted hazard ratio = 1.13). Conversely, PGF2α had no effect on the odds of cure of PVD [adjusted odds ratio (AOR) = 1.19], pregnancy at first service (AOR = 1.03), or pregnancy by 100 DIM (AOR = 0.89) or 200 DIM (AOR = 1.27). In conclusion, cows with VDS ≥1 can be considered to have PVD because of their lower hazard of pregnancy and longer calving to pregnancy interval (up to 48 d). Important risk factors are parity, calving, and body condition score loss peripartum. Optimal time of diagnosis is ≥28 to 35 DIM because cows experience a high self-cure rate. Self-cure is also affected by parity, prepartum BCS, and VDS. Finally, as treatment with one dose of PGF2α had a small effect on the hazard of pregnancy and no effect on clinical cure, its therapeutic use in grazing dairy cows with PVD is not recommended.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
American Dairy Science Association  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
Dairy Cow  
dc.subject
Prostaglandin F2α Treatment  
dc.subject
Purulent Vaginal Discharge  
dc.subject
Reproductive Efficiency  
dc.subject.classification
Otras Producción Animal y Lechería  
dc.subject.classification
Producción Animal y Lechería  
dc.subject.classification
CIENCIAS AGRÍCOLAS  
dc.title
Purulent vaginal discharge in grazing dairy cows: Risk factors, reproductive performance, and prostaglandin F2α treatment  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2018-10-23T15:50:56Z  
dc.journal.volume
100  
dc.journal.number
5  
dc.journal.pagination
3805-3815  
dc.journal.pais
Estados Unidos  
dc.journal.ciudad
Champaign, Illinois  
dc.description.fil
Fil: Giuliodori, Mauricio Javier. Facultad de Ciencias Veterinarias, Universidad Nacional de la Plata; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina  
dc.description.fil
Fil: Magnasco, M.. Estudio Magnasco; Argentina  
dc.description.fil
Fil: Magnasco, R.P.. Estudio Magnasco; Argentina  
dc.description.fil
Fil: Lacau, Isabel María. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina  
dc.description.fil
Fil: de la Sota, Rodolfo Luzbel. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina  
dc.journal.title
Journal of Dairy Science  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.journalofdairyscience.org/article/S0022-0302(17)30234-5/fulltext  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.3168/jds.2016-11373  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/pmid/28318582