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dc.contributor.author
Aloisio, Carolina
dc.contributor.author
Longhi, Marcela Raquel
dc.date.available
2018-10-23T15:10:59Z
dc.date.issued
2018-08
dc.identifier.citation
Aloisio, Carolina; Longhi, Marcela Raquel; Diloxanide furoate binary complexes with β-, methyl-β-, and hydroxypropyl-β-cyclodextrins: inclusion mode, characterization in solution and in solid state and in vitro dissolution studies; Taylor; Pharmaceutical Development and Technology; 23; 7; 8-2018; 723-731
dc.identifier.issn
1083-7450
dc.identifier.uri
http://hdl.handle.net/11336/62930
dc.description.abstract
The purpose of this study was to investigate the effect on solubility and dissolution rate of binary complexes of b -( b CD), methyl-(M b CD) and hydroxypropyl- b -cyclodextrin (HP b CD) with diloxanide furoate (DF).The complexation in solution was evaluated by phase solubility studies and1H nuclear magnetic resonance (NMR). Enhanced water solubility of DF was obtained with the DF:M b CD system (61-fold). The mode of inclusion was supported by NMR experiments, which indicated that real inclusion complexes wereformed between DF and M b CD or HP b CD. Solid state analysis was performed using infrared and thermal methods, which suggested the formation of true inclusion complexes of DF with two derivatized cyclodex-trins, M b CD and HP b CD, and an exclusion complex with b CD when the systems were prepared by freeze-dried technique. Dissolution studies conducted in simulated gastric fluid (2 h) and subsequent simulated intestinal fluid (next 4 h) showed increased dissolution rate of DF from the freeze-dried systems with b CD, M b CD, and HP b CD (85; 77 and 75% of dissolved drug at 5 min, respectively) and 100% of the drug dissolved at 150 min for the three systems. The enhancement of the solubility and the dissolution of DF observed make these complexes promising candidates for the preparation of oral pharmaceuticalformulations.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Taylor
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Complexation
dc.subject
Cyclodextrin
dc.subject
Diloxanide Furoate
dc.subject
In Vitro Dissolution
dc.subject
Mode of Interaction
dc.subject
Solid State Characterization
dc.subject.classification
Otras Ciencias Químicas
dc.subject.classification
Ciencias Químicas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.title
Diloxanide furoate binary complexes with β-, methyl-β-, and hydroxypropyl-β-cyclodextrins: inclusion mode, characterization in solution and in solid state and in vitro dissolution studies
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-10-22T19:35:15Z
dc.identifier.eissn
1097-9867
dc.journal.volume
23
dc.journal.number
7
dc.journal.pagination
723-731
dc.journal.pais
Reino Unido
dc.journal.ciudad
Londres
dc.description.fil
Fil: Aloisio, Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina
dc.description.fil
Fil: Longhi, Marcela Raquel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina
dc.journal.title
Pharmaceutical Development and Technology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1080/10837450.2017.1362435
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.tandfonline.com/doi/abs/10.1080/10837450.2017.1362435
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