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dc.contributor.author
Palmer, Clovis S.  
dc.contributor.author
Henstridge, Darren C.  
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Yu, Di  
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Singh, Amit  
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Balderson, Brad  
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Duette, Gabriel  
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Cherry, Catherine L.  
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Anzinger, Joshua J.  
dc.contributor.author
Ostrowski, Matias  
dc.contributor.author
Crowe, Suzanne M.  
dc.date.available
2018-10-22T22:35:36Z  
dc.date.issued
2016-06  
dc.identifier.citation
Palmer, Clovis S.; Henstridge, Darren C.; Yu, Di; Singh, Amit; Balderson, Brad; et al.; Emerging Role and Characterization of Immunometabolism: Relevance to HIV Pathogenesis, Serious Non-AIDS Events, and a Cure; American Association of Immunologists; Journal of Immunology; 196; 11; 6-2016; 4437-4444  
dc.identifier.issn
0022-1767  
dc.identifier.uri
http://hdl.handle.net/11336/62923  
dc.description.abstract
Immune cells cycle between a resting and an activated state. Their metabolism is tightly linked to their activation status and, consequently, functions. Ag recognition induces T lymphocyte activation and proliferation and acquisition of effector functions that require and depend on cellular metabolic reprogramming. Likewise, recognition of pathogen-associated molecular patterns by monocytes and macrophages induces changes in cellular metabolism. As obligate intracellular parasites, viruses manipulate the metabolism of infected cells to meet their structural and functional requirements. For example, HIV-induced changes in immune cell metabolism and redox state are associated with CD4+ T cell depletion, immune activation, and inflammation. In this review, we highlight how HIV modifies immunometabolism with potential implications for cure research and pathogenesis of comorbidities observed in HIV-infected patients, including those with virologic suppression. In addition, we highlight recently described key methods that can be applied to study the metabolic dysregulation of immune cells in disease states.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
American Association of Immunologists  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
Immunometabolism  
dc.subject
Hiv-1  
dc.subject.classification
Inmunología  
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Medicina Básica  
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CIENCIAS MÉDICAS Y DE LA SALUD  
dc.title
Emerging Role and Characterization of Immunometabolism: Relevance to HIV Pathogenesis, Serious Non-AIDS Events, and a Cure  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2018-10-09T21:22:32Z  
dc.identifier.eissn
1550-6606  
dc.journal.volume
196  
dc.journal.number
11  
dc.journal.pagination
4437-4444  
dc.journal.pais
Estados Unidos  
dc.journal.ciudad
Bethesda  
dc.description.fil
Fil: Palmer, Clovis S.. Monash University; Australia. Burnet Institute; Australia  
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Fil: Henstridge, Darren C.. Baker Heart and Diabetes Institute; Australia  
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Fil: Yu, Di. Monash University; Australia  
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Fil: Singh, Amit. Indian Institute of Science; India  
dc.description.fil
Fil: Balderson, Brad. Burnet Institute; Australia  
dc.description.fil
Fil: Duette, Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; Argentina  
dc.description.fil
Fil: Cherry, Catherine L.. Burnet Institute; Australia. Monash University; Australia. University of the Witwatersrand; Sudáfrica  
dc.description.fil
Fil: Anzinger, Joshua J.. University of the West Indies; Jamaica  
dc.description.fil
Fil: Ostrowski, Matias. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; Argentina  
dc.description.fil
Fil: Crowe, Suzanne M.. Monash University; Australia. Burnet Institute; Australia  
dc.journal.title
Journal of Immunology  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.4049/jimmunol.1600120  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.jimmunol.org/content/196/11/4437