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dc.contributor.author
Palmer, Clovis S.
dc.contributor.author
Henstridge, Darren C.
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Yu, Di
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Singh, Amit
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Balderson, Brad
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Duette, Gabriel
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Cherry, Catherine L.
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Anzinger, Joshua J.
dc.contributor.author
Ostrowski, Matias
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Crowe, Suzanne M.
dc.date.available
2018-10-22T22:35:36Z
dc.date.issued
2016-06
dc.identifier.citation
Palmer, Clovis S.; Henstridge, Darren C.; Yu, Di; Singh, Amit; Balderson, Brad; et al.; Emerging Role and Characterization of Immunometabolism: Relevance to HIV Pathogenesis, Serious Non-AIDS Events, and a Cure; American Association of Immunologists; Journal of Immunology; 196; 11; 6-2016; 4437-4444
dc.identifier.issn
0022-1767
dc.identifier.uri
http://hdl.handle.net/11336/62923
dc.description.abstract
Immune cells cycle between a resting and an activated state. Their metabolism is tightly linked to their activation status and, consequently, functions. Ag recognition induces T lymphocyte activation and proliferation and acquisition of effector functions that require and depend on cellular metabolic reprogramming. Likewise, recognition of pathogen-associated molecular patterns by monocytes and macrophages induces changes in cellular metabolism. As obligate intracellular parasites, viruses manipulate the metabolism of infected cells to meet their structural and functional requirements. For example, HIV-induced changes in immune cell metabolism and redox state are associated with CD4+ T cell depletion, immune activation, and inflammation. In this review, we highlight how HIV modifies immunometabolism with potential implications for cure research and pathogenesis of comorbidities observed in HIV-infected patients, including those with virologic suppression. In addition, we highlight recently described key methods that can be applied to study the metabolic dysregulation of immune cells in disease states.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
American Association of Immunologists
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Immunometabolism
dc.subject
Hiv-1
dc.subject.classification
Inmunología
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Emerging Role and Characterization of Immunometabolism: Relevance to HIV Pathogenesis, Serious Non-AIDS Events, and a Cure
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-10-09T21:22:32Z
dc.identifier.eissn
1550-6606
dc.journal.volume
196
dc.journal.number
11
dc.journal.pagination
4437-4444
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Bethesda
dc.description.fil
Fil: Palmer, Clovis S.. Monash University; Australia. Burnet Institute; Australia
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Fil: Henstridge, Darren C.. Baker Heart and Diabetes Institute; Australia
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Fil: Yu, Di. Monash University; Australia
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Fil: Singh, Amit. Indian Institute of Science; India
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Fil: Balderson, Brad. Burnet Institute; Australia
dc.description.fil
Fil: Duette, Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; Argentina
dc.description.fil
Fil: Cherry, Catherine L.. Burnet Institute; Australia. Monash University; Australia. University of the Witwatersrand; Sudáfrica
dc.description.fil
Fil: Anzinger, Joshua J.. University of the West Indies; Jamaica
dc.description.fil
Fil: Ostrowski, Matias. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; Argentina
dc.description.fil
Fil: Crowe, Suzanne M.. Monash University; Australia. Burnet Institute; Australia
dc.journal.title
Journal of Immunology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.4049/jimmunol.1600120
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.jimmunol.org/content/196/11/4437
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