Artículo
Antioxidant Activity and Acute Oral Tos Flowersxicity of Phrygilanthus acutifoliu
Daud, Adriana del Valle; Reynoso, Marcos Adrian
; Habib, Natalia Cecilia
; Sanchez Riera, Alicia Noemi
Fecha de publicación:
12/2010
Editorial:
Colegio de Farmacéuticos de la Provincia de Buenos Aires
Revista:
Acta Farmacéutica Bonaerense
ISSN:
0326-2383
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
SUMMARY. Antioxidant activity of ethanol and water extracts and infusion of the flowers of Phrygilanthus acutifolius were evaluated. Total phenolic contents were determined using Folin- Ciocalteau reagent. The ethanol extract was more effective in scavenging radical 1,1 biphenyl -2-picrylhydrazyl (DPPH), with lower IC50 values. The water and ethanol extracts were the most effective antioxidants based on the inhibition of lipid peroxidation (β carotene bleaching method). The acute toxicity test in rats indicated that oral administration of 3.200 mg/Kg of flowers produced neither mortality, nor changes in behaviour or any other physiological activities. There were no significant differences in the body and organ weight between controls and treated animals. In blood chemistry analysis, aspartate transaminase, alanine transaminase, and alkaline phosphatase activities, no significant changes occurred. In view of the doses consumed empirically in traditional medicine of Amaicha del Valle, Tucumán, Argentina, there is a wide margin of safety for the therapeutic use of Phrygilanthus acutifolius flowers.
Palabras clave:
Antioxidant
,
Activity
,
Acute
,
Toxocity
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Articulos(INSIBIO)
Articulos de INST.SUP.DE INVEST.BIOLOGICAS
Articulos de INST.SUP.DE INVEST.BIOLOGICAS
Citación
Daud, Adriana del Valle; Reynoso, Marcos Adrian; Habib, Natalia Cecilia; Sanchez Riera, Alicia Noemi; Antioxidant Activity and Acute Oral Tos Flowersxicity of Phrygilanthus acutifoliu; Colegio de Farmacéuticos de la Provincia de Buenos Aires; Acta Farmacéutica Bonaerense; 29; 5; 12-2010; 783-788
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