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Artículo

Effects of 17β-estradiol on the cytoarchitecture of pyramidal CA1 neurons in normoglycemic and diabetic male spontaneously hypertensive rats

Brocca, María ElviraIcon ; Pietranera, LucianaIcon ; Roig, PaulinaIcon ; Lima, Analia EthelIcon ; de Nicola, Alejandro FedericoIcon
Fecha de publicación: 07/11/2014
Editorial: Elsevier
Revista: Neuroscience
ISSN: 0306-4522
e-ISSN: 1873-7544
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Neurociencias

Resumen

Previous work has shown a reduction of apical dendritic length and spine density in neurons from the CA1 hippocampus subfield of spontaneously hypertensive rats (SHR). These abnormalities are prevented by treatment for 2 weeks with 17 beta-estradiol. In view of the fact that diabetes and hypertension are comorbid diseases, we have now studied the effect of Streptozotocin-induced diabetes on the dendritic tree and spines of CA1 hippocampus neurons, and also compared the regulation of these parameters by 17 beta-estradiol in diabetic and normoglycemic SHR. Twenty week old male SHR received iv 40 mg/kg Streptozotocin or vehicle and studied one month afterwards. A group of normoglycemic and hyperglycemic SHR also received sc a single 17 beta-estradiol pellet or vehicle for 2 weeks. Hippocampus sections were impregnated with silver nitrate following a modified Golgi´s method and the arbor of CA1 pyramidal neurons analyzed by the Sholl´s method. 17 betaestradiol treatment of normoglycemic SHR reversed the reduced length of apical dendrites, the low spine density and additionally decreased blood pressure. Diabetic SHR showed increased length of apical and basal dendrites but reduced spine density compared to normoglycemic SHR. Diabetes also decreased blood pressure of SHR. Treatment with 17 beta-estradiol of diabetic SHR enhanced dendritic length, increased dendritic spine density and further decreased blood pressure. Thus, changes of cytoarchitecture of CA1 neurons due to 17 beta-estradiol treatment of normoglycemic SHR persisted after diabetes induction. A decrease of blood pressure may also contribute to the central effects of 17beta-estradiol in SHR diabetic rats.
Palabras clave: Hippocampus , 17beta-Estradiol , Dendrites , Spines , Diabetes_Mellitus , Spontaneously_Hypertensive_Rat
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Atribución-NoComercial-SinDerivadas 2.5 Argentina (CC BY-NC-ND 2.5 AR)
Identificadores
URI: http://hdl.handle.net/11336/6288
DOI: http://dx.doi.org/10.1016/j.neuroscience.2014.09.030
DOI: http://dx.doi.org/ 10.1016/j.neuroscience.2014.09.030
URL: http://www.sciencedirect.com/science/article/pii/S0306452214007799
Colecciones
Articulos(IBYME)
Articulos de INST.DE BIOLOGIA Y MEDICINA EXPERIMENTAL (I)
Articulos(OCA HOUSSAY)
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA HOUSSAY
Citación
Brocca, María Elvira; Pietranera, Luciana; Roig, Paulina; Lima, Analia Ethel; de Nicola, Alejandro Federico; Effects of 17β-estradiol on the cytoarchitecture of pyramidal CA1 neurons in normoglycemic and diabetic male spontaneously hypertensive rats; Elsevier; Neuroscience; 280; 7-11-2014; 243-253
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