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dc.contributor.author
Kruse, Maria Sol
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dc.contributor.author
Vega, Maria Cristina
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dc.contributor.author
Rey, Mariana
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dc.contributor.author
Coirini, Hector
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dc.date.available
2016-07-01T16:05:10Z
dc.date.issued
2014-05-13
dc.identifier.citation
Kruse, Maria Sol; Vega, Maria Cristina; Rey, Mariana; Coirini, Hector; Sex differences in LXR expression in LXR expression in normal offspring and in rats born from diabetic dams; Bioscientifica; Journal of Endocrinology; 222; 13-5-2014; 53-60
dc.identifier.issn
0022-0795
dc.identifier.issn
1479-6805
dc.identifier.uri
http://hdl.handle.net/11336/6287
dc.description.abstract
Gestational diabetes (GD) alters normal fetal development and is related to a diabetogenic effect in the progeny. Liver X receptors (LXRs) are considered to be potential drug targets for the regulation, treatment, or prevention of diabetes. The aim of this study was to evaluate early and late changes of LXR in the hippocampus and hypothalamus of the male and female offspring of control (CO) and diabetic (DO) mothers. We used an experimental model of streptozotocin-induced GD to assess the protein expression of LXRα (NR1H3) and LXRβ (NR1H2) by western blotting. The tissues were obtained from CO and DO animals at postnatal day 1 (1D), day 10 (10D), and day 35 (35D) and 9 months (9M). In CO, the LXR expression showed significant differences among the groups, which were tissue- and receptor-specific (P<0.05). Sex differences in CO were found only in the hypothalamus for LXRβ expression at 35D and 9M (P<0.05). When CO and DO were compared, differences between them were observed in the majority of the studied groups at 1D (male hippocampus, LXRα 31% and LXRβ 161%; female hippocampus, LXRβ 165%; male hypothalamus, LXRβ 182%; and female hypothalamus, LXRα 85%; P<0.05). However, these differences disappeared later with the exception of LXRβ expression in the male hypothalamus (P<0.05). The area under the curve during the glucose tolerance test correlated negatively with LXRβ in CO but not in DO animals. Moreover, in a male DO subpopulation this correlation was positive as it occurs in intolerant animals. These results indicate that GD affects hypothalamic LXR expression differently in male and female offspring.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Bioscientifica
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Glucose Tolerance Test
dc.subject
Auc
dc.subject
Gestational Diabetes
dc.subject
Insulin Resistance
dc.subject
Diabetes Mellitus Experimental
dc.subject.classification
Neurociencias
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dc.subject.classification
Medicina Básica
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Sex differences in LXR expression in LXR expression in normal offspring and in rats born from diabetic dams
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2016-06-15T19:12:19Z
dc.journal.volume
222
dc.journal.pagination
53-60
dc.journal.pais
Reino Unido
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dc.journal.ciudad
Bristol
dc.conicet.avisoEditorial
Disclaimer: this is not the definitive version of record of this article.This manuscript has been accepted for publication in Journal of endocrinology, but the version presented here has not yet been copy-edited, formatted or proofed. Consequently, Bioscientifica accepts no responsibility for any errors or omissions it may contain. The definitive version is now freely available at http://dx.doi.org/10.1530/JOE-14-0054 2014
dc.description.fil
Fil: Kruse, Maria Sol. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina
dc.description.fil
Fil: Vega, Maria Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina
dc.description.fil
Fil: Rey, Mariana. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina
dc.description.fil
Fil: Coirini, Hector. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina. Universidad Catolica de Cuyo - Sede San Juan; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana; Argentina
dc.journal.title
Journal of Endocrinology
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1530/JOE-14-0054.
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://joe.endocrinology-journals.org/content/222/1/53
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