Artículo

Antifungal activity of a novel quercetin derivative bearing a trifluoromethyl group on Candida albicans

Tempesti, Tomas CristianIcon ; Alvarez, María GabrielaIcon ; de Araújo, Marcelo Francisco; Catunda Júnior, Francisco Eduardo Aragão; de Carvalho, Mário Geraldo; Durantini, Edgardo NéstorIcon
Fecha de publicación: 09/2012
Editorial: Birkhauser Boston Inc
Revista: Medicinal Chemistry Research
ISSN: 1054-2523
e-ISSN: 1554-8120
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:

Resumen

In this study, a novel quercetin derivative bearing a trifluoromethyl group was synthesized by the nucleophilic aromatic substitution reaction between rutin and 2-chloro-5-(trifluoromethyl)-1,3-dinitrobenzene in basic medium. This synthetic quercetin showed antifungal activity against Candida albicans cultures. The results indicated a remarkable increase in the biological activity of this compound as compared to rutin.
Palabras clave: Antifungal Activity , Candida Albicans , Flavonoid , Quercetin , Rutin
 
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/62845
URL: https://link.springer.com/article/10.1007%2Fs00044-011-9750-x
DOI: http://dx.doi.org/10.1007/s00044-011-9750-x
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Articulos(INFIQC)
Articulos de INST.DE INVESTIGACIONES EN FISICO- QUIMICA DE CORDOBA
Citación
Tempesti, Tomas Cristian; Alvarez, María Gabriela; de Araújo, Marcelo Francisco; Catunda Júnior, Francisco Eduardo Aragão; de Carvalho, Mário Geraldo; et al.; Antifungal activity of a novel quercetin derivative bearing a trifluoromethyl group on Candida albicans; Birkhauser Boston Inc; Medicinal Chemistry Research; 21; 9; 9-2012; 2217-2222
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