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dc.contributor.author
Joo Turoni, Claudio Martín
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dc.contributor.author
Marañón, Rodrigo Oscar
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dc.contributor.author
Proto, Victor
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dc.contributor.author
Herrera, Ramon Nicasio Gerardo
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dc.contributor.author
Peral, Maria de Los Angeles
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dc.date.available
2018-10-19T20:11:55Z
dc.date.issued
2011-01
dc.identifier.citation
Joo Turoni, Claudio Martín; Marañón, Rodrigo Oscar; Proto, Victor; Herrera, Ramon Nicasio Gerardo; Peral, Maria de Los Angeles; Nitric oxide modulates reactivity to angiotensin II in internal mammary arterial grafts in hytertensive patients without associated risk factors; Taylor & Francis; Clinical and Experimental Hypertension; 33; 1; 1-2011; 27-33
dc.identifier.issn
1064-1963
dc.identifier.uri
http://hdl.handle.net/11336/62829
dc.description.abstract
We investigated the effects of extraendothelial nitric oxide (NO) on angiotensin II (Ang II) reactivity in internal mammary artery (IMA) rings, as well as the impact of hypertension without associated risk factors in this response. Vascular reactivity, NO levels, and resting membrane potentials were determined in hypertensive (HT) and normotensive (NT) IMA rings. Only rings with endothelial dysfunction were included. Ang II produced a dose-dependent contraction that was higher in HT rings. Response to Ang II was potentiated by Nω-nitro L-arginine methyl ester (L-NAME) in NT but not in HT rings. The antioxidant agents tempol and diphenyleneiodonium (DPI) reverted the hyperreactivity to Ang II in HT rings. Extraendothelial NO was present in both NT and HT rings. However, NT rings showed higher values. LNAME and S-methyl-L-thiocitrulline inhibited NO release in all cases. L-arginine reverted this inhibition. Both tempol and DPI increased NO release in both NT and HT rings. The number of vascular smooth muscle cells (VSMC) and anti-α-actin positive areas were lower in HT than in NT rings, without variations in wall thickness or wall/lumen ratio. With regard to resting membrane potential, we found in HT rings that the depolarization induced by Ang II was abolished by tempol. These findings suggest that extraendothelial NO counterregulates Ang II contractility in IMA rings; however, its action could be altered in hypertensive situations even though the patients did not have associated risk factors. We suggest two mechanisms: increased oxidative stress and a decreased ability of nNOS in VSMC to produce NO.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Taylor & Francis
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Angiotensin Ii
dc.subject
Bypass Graft
dc.subject
Coronary Arteries
dc.subject
Endothelial Dysfunction
dc.subject
Hypertension
dc.subject
Nitric Oxide (No)
dc.subject.classification
Biología Celular, Microbiología
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dc.subject.classification
Ciencias Biológicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
Nitric oxide modulates reactivity to angiotensin II in internal mammary arterial grafts in hytertensive patients without associated risk factors
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-10-17T15:03:39Z
dc.journal.volume
33
dc.journal.number
1
dc.journal.pagination
27-33
dc.journal.pais
Estados Unidos
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dc.journal.ciudad
Nueva York
dc.description.fil
Fil: Joo Turoni, Claudio Martín. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; Argentina
dc.description.fil
Fil: Marañón, Rodrigo Oscar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; Argentina
dc.description.fil
Fil: Proto, Victor. Centro Modelo de Cardiología; Argentina
dc.description.fil
Fil: Herrera, Ramon Nicasio Gerardo. Centro Modelo de Cardiología; Argentina
dc.description.fil
Fil: Peral, Maria de Los Angeles. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; Argentina
dc.journal.title
Clinical and Experimental Hypertension
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://informahealthcare.com/doi/abs/10.3109/10641963.2010.503297
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.3109/10641963.2010.503297
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