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dc.contributor.author
Fernandez Calotti, Paula  
dc.contributor.author
Jordheim, Lars Petter  
dc.contributor.author
Giordano, Mirta Nilda  
dc.contributor.author
Dumontet, Charles  
dc.contributor.author
Galmarini, Carlos Maria  
dc.date.available
2018-10-17T17:47:19Z  
dc.date.issued
2005-03  
dc.identifier.citation
Fernandez Calotti, Paula; Jordheim, Lars Petter; Giordano, Mirta Nilda; Dumontet, Charles; Galmarini, Carlos Maria; Substrate cycles and drug resistance to 1-beta-D-arabinofuranosylcytosine (araC); Taylor & Francis Ltd; Leukemia and Lymphoma; 46; 3; 3-2005; 335-346  
dc.identifier.issn
1042-8194  
dc.identifier.uri
http://hdl.handle.net/11336/62580  
dc.description.abstract
Acute myelogenous leukemia (AML) is the most common form of acute leukemia in adults. After diagnosis, patients with AML are mainly treated with standard induction chemotherapy combining cytarabine (araC) and anthracyclines. The majority of them achieve complete remission (CR) (65-80%). However, prospects for long-term survival are poor for the majority of patients. Resistance to chemotherapy therefore remains a major obstacle in the effective treatment of patients with AML. In this review, we highlight the current knowledge of substrate cycles involved in normal deoxynucleoside triphosphate (dNTPs) metabolism and their possible role in drug resistance to araC. © 2005 Taylor & Francis Group Ltd.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Taylor & Francis Ltd  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
Aml  
dc.subject
Arac  
dc.subject
Nucleotide Metabolism  
dc.subject.classification
Inmunología  
dc.subject.classification
Medicina Básica  
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD  
dc.title
Substrate cycles and drug resistance to 1-beta-D-arabinofuranosylcytosine (araC)  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2018-10-12T17:26:48Z  
dc.journal.volume
46  
dc.journal.number
3  
dc.journal.pagination
335-346  
dc.journal.pais
Reino Unido  
dc.journal.ciudad
Londres  
dc.description.fil
Fil: Fernandez Calotti, Paula. Academia Nacional de Medicina de Buenos Aires; Argentina  
dc.description.fil
Fil: Jordheim, Lars Petter. Université Claude Bernard Lyon 1; Francia  
dc.description.fil
Fil: Giordano, Mirta Nilda. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Academia Nacional de Medicina de Buenos Aires; Argentina  
dc.description.fil
Fil: Dumontet, Charles. Université Claude Bernard Lyon 1; Francia  
dc.description.fil
Fil: Galmarini, Carlos Maria. Université Claude Bernard Lyon 1; Francia  
dc.journal.title
Leukemia and Lymphoma  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.1080/10428190400015683  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.tandfonline.com/doi/abs/10.1080/10428190400015683  

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