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dc.contributor.author
Labovsky, Vivian
dc.contributor.author
Martinez, Leandro Marcelo
dc.contributor.author
Calcagno, María de Luján
dc.contributor.author
Davies, Kevin Mauro
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Garcia Rivello, Hernan Jorge
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Wernicke, Alejandra
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Feldman, Leonardo
dc.contributor.author
Giorello, Maria Belen
dc.contributor.author
Matas, Ayelen
dc.contributor.author
Borzone, Francisco Raúl
dc.contributor.author
Howard, Scott C.
dc.contributor.author
Chasseing, Norma Alejandra
dc.date.available
2018-10-17T15:55:18Z
dc.date.issued
2016-10
dc.identifier.citation
Labovsky, Vivian; Martinez, Leandro Marcelo; Calcagno, María de Luján; Davies, Kevin Mauro; Garcia Rivello, Hernan Jorge; et al.; Interleukin-6 receptor in spindle-shaped stromal cells, a prognostic determinant of early breast cancer; Karger; Tumor Biology; 37; 10; 10-2016; 13377-13384
dc.identifier.issn
1010-4283
dc.identifier.uri
http://hdl.handle.net/11336/62556
dc.description.abstract
Spindle-shaped stromal cells, like carcinoma-associated fibroblasts and mesenchymal stem cells, influence tumor behavior and can serve as parameters in the clinical diagnosis, therapy, and prognosis of early breast cancer. Therefore, the aim of this study is to explore the clinicopathological significance of tumor necrosis factor-related apoptosis-induced ligand (TRAIL) receptors (Rs) 2 and 4 (TRAIL-R2 and R4), and interleukin-6 R (IL-6R) in spindle-shaped stromal cells, not associated with the vasculature, as prognostic determinants of early breast cancer patients. Receptors are able to trigger the migratory activity, among other functions, of these stromal cells. We conducted immunohistochemical analysis for the expression of these receptors in spindle-shaped stromal cells, not associated with the vasculature, of primary tumors from early invasive breast cancer patients, and analyzed their association with clinicopathological characteristics. Here, we demonstrate that the elevated levels of TRAIL-R2, TRAIL-R4, and IL-6R in these stromal cells were significantly associated with a higher risk of metastatic occurrence (p = 0.034, 0.026, and 0.006; respectively). Moreover, high expression of TRAIL-R4 was associated with shorter disease-free survival and metastasis-free survival (p = 0.013 and 0.019; respectively). Also, high expression of IL-6R was associated with shorter disease-free survival, metastasis-free survival, and overall survival (p = 0.003, 0.001, and 0.003; respectively). Multivariate analysis showed that IL-6R expression was an independent prognostic factor for disease-free survival and metastasis-free survival (p = 0.035). This study is the first to demonstrate that high levels of IL-6R expression in spindle-shaped stromal cells, not associated with the vasculature, could be used to identify early breast cancer patients with poor outcomes.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Karger
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc/2.5/ar/
dc.subject
Breast Cancer
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Cancer Associated Fibroblasts
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Interleukin-6 Receptor
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Mesenchymal Stem Cells
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Spindle-Shaped Stromal Cells
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Patología
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Interleukin-6 receptor in spindle-shaped stromal cells, a prognostic determinant of early breast cancer
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-10-01T15:02:54Z
dc.journal.volume
37
dc.journal.number
10
dc.journal.pagination
13377-13384
dc.journal.pais
Suiza
dc.journal.ciudad
Basel
dc.description.fil
Fil: Labovsky, Vivian. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
dc.description.fil
Fil: Martinez, Leandro Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
dc.description.fil
Fil: Calcagno, María de Luján. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
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Fil: Davies, Kevin Mauro. Hospital Italiano; Argentina
dc.description.fil
Fil: Garcia Rivello, Hernan Jorge. Hospital Italiano; Argentina
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Fil: Wernicke, Alejandra. Hospital Italiano; Argentina
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Fil: Feldman, Leonardo. Fundación Favaloro; Argentina
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Fil: Giorello, Maria Belen. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
dc.description.fil
Fil: Matas, Ayelen. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
dc.description.fil
Fil: Borzone, Francisco Raúl. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
dc.description.fil
Fil: Howard, Scott C.. University of Memphis; Estados Unidos
dc.description.fil
Fil: Chasseing, Norma Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.journal.title
Tumor Biology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007/s13277-016-5268-7
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1007/s13277-016-5268-7
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