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dc.contributor.author
Gontero, Daniela Ivana
dc.contributor.author
Veglia, Alicia Viviana
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dc.contributor.author
Bracamonte, Angel Guillermo
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dc.contributor.author
Boudreau, Denis
dc.date.available
2018-10-12T17:17:23Z
dc.date.issued
2017-02-06
dc.identifier.citation
Gontero, Daniela Ivana; Veglia, Alicia Viviana; Bracamonte, Angel Guillermo; Boudreau, Denis; Synthesis of ultraluminescent gold core-shell nanoparticles as nanoimaging platforms for biosensing applications based on metal-enhanced fluorescence; Royal Society of Chemistry; RSC Advances; 7; 17; 6-2-2017; 10252-10258
dc.identifier.issn
2046-2069
dc.identifier.uri
http://hdl.handle.net/11336/62314
dc.description.abstract
Core-shell nanoparticles are versatile nanostructures that can be used as luminescent biosensing platforms in many nanotechnological developments. Ultraluminescent fluorescent gold core-shell nanoparticles based on Metal-Enhanced Fluorescence (MEF) were synthesized. The nanoparticles obtained were formed by 40.0 nm cores and variable silica spacer lengths. Silica spacer lengths from 6.0 to 25.0 nm were obtained. The plasmon maximal wavelength of the core-shell nanoparticles was shifted to a longer wavelength from a gold nanoparticle plasmon centered at 537.0 nm to 545.0 nm and 548 nm from 6.0 nm to 20.0 nm spacer length, respectively. The effect of the gold core on emission was evaluated by determination of Metal Enhanced Fluorescence enhancement factors (MEFEF), applying the sodium cyanide method for core leaching. We observed maximal MEFEF = 8.1 and 7.2 for 6.0 and 14.0 nm, respectively, and a significant decrease at longer silica spacer lengths. From nanoimaging by confocal fluorescence microscopy it was possible to detect ultraluminescent gold core-shell nanoparticle aggregates and obtain an MEFEF that can rise to 40. These parameters and properties were discussed from the point of view of fluorescent platform applications. Moreover in order to show the potential application of these nanoparticles in biodetection and nanomedicine, Escherichia coli bacteria were labelled with ultraluminescent nanoparticles. Bright and clear bacteria images were obtained by laser fluorescence microscopy. Based on these results, future applications for individual bacterial detection will be developed.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Royal Society of Chemistry
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Nanoparticles
dc.subject
Fluorescence
dc.subject
Bacteria
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Detection
dc.subject.classification
Otras Ciencias Químicas
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dc.subject.classification
Ciencias Químicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
Synthesis of ultraluminescent gold core-shell nanoparticles as nanoimaging platforms for biosensing applications based on metal-enhanced fluorescence
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-09-10T15:47:24Z
dc.identifier.eissn
2046-2069
dc.journal.volume
7
dc.journal.number
17
dc.journal.pagination
10252-10258
dc.journal.pais
Reino Unido
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dc.journal.ciudad
Londres
dc.description.fil
Fil: Gontero, Daniela Ivana. Clínica de la Familia II. Laboratorio de Análisis Clínicos y Bacteriológicos; Argentina
dc.description.fil
Fil: Veglia, Alicia Viviana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; Argentina
dc.description.fil
Fil: Bracamonte, Angel Guillermo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; Argentina
dc.description.fil
Fil: Boudreau, Denis. Universite Laval; Francia
dc.journal.title
RSC Advances
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://pubs.rsc.org/en/Content/ArticleLanding/2017/RA/C6RA27649K
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.1039/c6ra27649k
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