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dc.contributor.author
Puttur, Franz
dc.contributor.author
Francozo, Marcela
dc.contributor.author
Solmaz, Gülhas
dc.contributor.author
Bueno, Carlos Alberto
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Lindenberg, Marc
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Gohmert, Melanie
dc.contributor.author
Swallow, Maxine
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Tufa, Dejene
dc.contributor.author
Jacobs, Roland
dc.contributor.author
Lienenklaus, Stefan
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Kühl, Anja A.
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Borkner, Lisa
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Cicin-Sain, Luka
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Holzmann, Bernard
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Wagner, Hermann
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Berod, Luciana
dc.contributor.author
Sparwasser, Tim
dc.date.available
2018-10-12T13:26:27Z
dc.date.issued
2016-10
dc.identifier.citation
Puttur, Franz; Francozo, Marcela; Solmaz, Gülhas; Bueno, Carlos Alberto; Lindenberg, Marc; et al.; Conventional Dendritic Cells Confer Protection against Mouse Cytomegalovirus Infection via TLR9 and MyD88 Signaling; Elsevier Science; Cell Reports; 17; 4; 10-2016; 1113-1127
dc.identifier.issn
2211-1247
dc.identifier.uri
http://hdl.handle.net/11336/62282
dc.description.abstract
Cytomegalovirus (CMV) is an opportunistic virus severely infecting immunocompromised individuals. In mice, endosomal Toll-like receptor 9 (TLR9) and downstream myeloid differentiation factor 88 (MyD88) are central to activating innate immune responses against mouse CMV (MCMV). In this respect, the cell-specific contribution of these pathways in initiating anti-MCMV immunity remains unclear. Using transgenic mice, we demonstrate that TLR9/MyD88 signaling selectively in CD11c+ dendritic cells (DCs) strongly enhances MCMV clearance by boosting natural killer (NK) cell CD69 expression and IFN-γ production. In addition, we show that in the absence of plasmacytoid DCs (pDCs), conventional DCs (cDCs) promote robust NK cell effector function and MCMV clearance in a TLR9/MyD88-dependent manner. Simultaneously, cDC-derived IL-15 regulates NK cell degranulation by TLR9/MyD88-independent mechanisms. Overall, we compartmentalize the cellular contribution of TLR9 and MyD88 signaling in individual DC subsets and evaluate the mechanism by which cDCs control MCMV immunity.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier Science
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject
Conventional Dc
dc.subject
Mcmv
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Nk Cells
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Plasmacytoid Dc
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Tlr9-Myd88 Signaling
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Inmunología
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Conventional Dendritic Cells Confer Protection against Mouse Cytomegalovirus Infection via TLR9 and MyD88 Signaling
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-08-30T15:11:01Z
dc.journal.volume
17
dc.journal.number
4
dc.journal.pagination
1113-1127
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Cambridge
dc.description.fil
Fil: Puttur, Franz. Centre for Experimental and Clinical Infection Research; Alemania
dc.description.fil
Fil: Francozo, Marcela. Centre for Experimental and Clinical Infection Research; Alemania. Universidade de Sao Paulo; Brasil
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Fil: Solmaz, Gülhas. Centre for Experimental and Clinical Infection Research; Alemania
dc.description.fil
Fil: Bueno, Carlos Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; Argentina. Centre for Experimental and Clinical Infection Research; Alemania
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Fil: Lindenberg, Marc. Centre for Experimental and Clinical Infection Research; Alemania
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Fil: Gohmert, Melanie. Centre for Experimental and Clinical Infection Research; Alemania
dc.description.fil
Fil: Swallow, Maxine. Centre for Experimental and Clinical Infection Research; Alemania
dc.description.fil
Fil: Tufa, Dejene. Department of Clinical Immunology and Rheumatology; Alemania
dc.description.fil
Fil: Jacobs, Roland. Department of Clinical Immunology and Rheumatology; Alemania
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Fil: Lienenklaus, Stefan. Institute for Laboratory Animal Science; Alemania. Institute for Experimental Infection Research; Alemania
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Fil: Kühl, Anja A.. Charité–Universitätsmedizin Berlin; Alemania
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Fil: Borkner, Lisa. Department for Vaccinology/Immune Aging and Chronic Infection; Alemania
dc.description.fil
Fil: Cicin-Sain, Luka. Department for Vaccinology/Immune Aging and Chronic Infection; Alemania
dc.description.fil
Fil: Holzmann, Bernard. Technische Universitat Munchen; Alemania
dc.description.fil
Fil: Wagner, Hermann. Technische Universitat Munchen; Alemania
dc.description.fil
Fil: Berod, Luciana. Centre for Experimental and Clinical Infection Research; Alemania
dc.description.fil
Fil: Sparwasser, Tim. Centre for Experimental and Clinical Infection Research; Alemania
dc.journal.title
Cell Reports
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.1016/j.celrep.2016.09.055
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S2211124716312943
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