Mostrar el registro sencillo del ítem

dc.contributor.author
Zalcman, Gisela Patricia
dc.contributor.author
Corbi, Nicoletta
dc.contributor.author
Di Certo, Maria Grazia
dc.contributor.author
Mattei, Elisabetta
dc.contributor.author
Federman, Maria Noel
dc.contributor.author
Romano, Arturo Gabriel
dc.date.available
2018-10-11T20:52:11Z
dc.date.issued
2016-10
dc.identifier.citation
Zalcman, Gisela Patricia; Corbi, Nicoletta; Di Certo, Maria Grazia; Mattei, Elisabetta; Federman, Maria Noel; et al.; Heterozygous Che-1 KO mice show deficiencies in object recognition memory persistence; Elsevier Ireland; Neuroscience Letters; 632; 10-2016; 169-174
dc.identifier.issn
0304-3940
dc.identifier.uri
http://hdl.handle.net/11336/62268
dc.description.abstract
Transcriptional regulation is a key process in the formation of long-term memories. Che-1 is a protein involved in the regulation of gene transcription that has recently been proved to bind the transcription factor NF-κB, which is known to be involved in many memory-related molecular events. This evidence prompted us to investigate the putative role of Che-1 in memory processes. For this study we newly generated a line of Che-1+/− heterozygous mice. Che-1 homozygous KO mouse is lethal during development, but Che-1+/− heterozygous mouse is normal in its general anatomical and physiological characteristics. We analyzed the behavioral characteristic and memory performance of Che-1+/− mice in two NF-κB dependent types of memory. We found that Che-1+/− mice show similar locomotor activity and thigmotactic behavior than wild type (WT) mice in an open field. In a similar way, no differences were found in anxiety-like behavior between Che-1+/− and WT mice in an elevated plus maze as well as in fear response in a contextual fear conditioning (CFC) and object exploration in a novel object recognition (NOR) task. No differences were found between WT and Che-1+/− mice performance in CFC training and when tested at 24 h or 7 days after training. Similar performance was found between groups in NOR task, both in training and 24 h testing performance. However, we found that object recognition memory persistence at 7 days was impaired in Che-1+/− heterozygous mice. This is the first evidence showing that Che-1 is involved in memory processes.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier Ireland
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject
CHE-1
dc.subject
FEAR CONDITIONING
dc.subject
GENE TRANSCRIPTION
dc.subject
LONG-TERM MEMORY
dc.subject
MEMORY PERSISTENCE
dc.subject
MOUSE
dc.subject
NOVEL OBJECT RECOGNITION
dc.subject.classification
Otras Ciencias Biológicas
dc.subject.classification
Ciencias Biológicas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.title
Heterozygous Che-1 KO mice show deficiencies in object recognition memory persistence
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-10-09T21:22:13Z
dc.journal.volume
632
dc.journal.pagination
169-174
dc.journal.pais
Irlanda
dc.journal.ciudad
Limerick
dc.description.fil
Fil: Zalcman, Gisela Patricia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina
dc.description.fil
Fil: Corbi, Nicoletta. Università degli studi di Roma "La Sapienza"; Italia
dc.description.fil
Fil: Di Certo, Maria Grazia. Centre National de la Recherche Scientifique; Francia
dc.description.fil
Fil: Mattei, Elisabetta. Centre National de la Recherche Scientifique; Francia
dc.description.fil
Fil: Federman, Maria Noel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina
dc.description.fil
Fil: Romano, Arturo Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina
dc.journal.title
Neuroscience Letters
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://linkinghub.elsevier.com/retrieve/pii/S0304394016306553
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.neulet.2016.08.055