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dc.contributor.author
Zalcman, Gisela Patricia
dc.contributor.author
Corbi, Nicoletta
dc.contributor.author
Di Certo, Maria Grazia
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Mattei, Elisabetta
dc.contributor.author
Federman, Maria Noel
dc.contributor.author
Romano, Arturo Gabriel
dc.date.available
2018-10-11T20:52:11Z
dc.date.issued
2016-10
dc.identifier.citation
Zalcman, Gisela Patricia; Corbi, Nicoletta; Di Certo, Maria Grazia; Mattei, Elisabetta; Federman, Maria Noel; et al.; Heterozygous Che-1 KO mice show deficiencies in object recognition memory persistence; Elsevier Ireland; Neuroscience Letters; 632; 10-2016; 169-174
dc.identifier.issn
0304-3940
dc.identifier.uri
http://hdl.handle.net/11336/62268
dc.description.abstract
Transcriptional regulation is a key process in the formation of long-term memories. Che-1 is a protein involved in the regulation of gene transcription that has recently been proved to bind the transcription factor NF-κB, which is known to be involved in many memory-related molecular events. This evidence prompted us to investigate the putative role of Che-1 in memory processes. For this study we newly generated a line of Che-1+/− heterozygous mice. Che-1 homozygous KO mouse is lethal during development, but Che-1+/− heterozygous mouse is normal in its general anatomical and physiological characteristics. We analyzed the behavioral characteristic and memory performance of Che-1+/− mice in two NF-κB dependent types of memory. We found that Che-1+/− mice show similar locomotor activity and thigmotactic behavior than wild type (WT) mice in an open field. In a similar way, no differences were found in anxiety-like behavior between Che-1+/− and WT mice in an elevated plus maze as well as in fear response in a contextual fear conditioning (CFC) and object exploration in a novel object recognition (NOR) task. No differences were found between WT and Che-1+/− mice performance in CFC training and when tested at 24 h or 7 days after training. Similar performance was found between groups in NOR task, both in training and 24 h testing performance. However, we found that object recognition memory persistence at 7 days was impaired in Che-1+/− heterozygous mice. This is the first evidence showing that Che-1 is involved in memory processes.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier Ireland
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject
CHE-1
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FEAR CONDITIONING
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GENE TRANSCRIPTION
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LONG-TERM MEMORY
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MEMORY PERSISTENCE
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MOUSE
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NOVEL OBJECT RECOGNITION
dc.subject.classification
Otras Ciencias Biológicas
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Ciencias Biológicas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.title
Heterozygous Che-1 KO mice show deficiencies in object recognition memory persistence
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-10-09T21:22:13Z
dc.journal.volume
632
dc.journal.pagination
169-174
dc.journal.pais
Irlanda
dc.journal.ciudad
Limerick
dc.description.fil
Fil: Zalcman, Gisela Patricia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina
dc.description.fil
Fil: Corbi, Nicoletta. Università degli studi di Roma "La Sapienza"; Italia
dc.description.fil
Fil: Di Certo, Maria Grazia. Centre National de la Recherche Scientifique; Francia
dc.description.fil
Fil: Mattei, Elisabetta. Centre National de la Recherche Scientifique; Francia
dc.description.fil
Fil: Federman, Maria Noel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina
dc.description.fil
Fil: Romano, Arturo Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina
dc.journal.title
Neuroscience Letters
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://linkinghub.elsevier.com/retrieve/pii/S0304394016306553
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.neulet.2016.08.055
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