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dc.contributor.author
Valverde, Carlos Alfredo
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dc.contributor.author
Kornyeyev, Dmytro
dc.contributor.author
Ferreiro, Marcela
dc.contributor.author
Petrosky, Azadé D.
dc.contributor.author
Mattiazzi, Ramona Alicia
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dc.contributor.author
Escobar, Ariel Luis Manuel
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dc.date.available
2018-10-09T16:34:07Z
dc.date.issued
2010-03
dc.identifier.citation
Valverde, Carlos Alfredo; Kornyeyev, Dmytro; Ferreiro, Marcela; Petrosky, Azadé D.; Mattiazzi, Ramona Alicia; et al.; Transient Ca2+ depletion of the sarcoplasmic reticulum at the onset of reperfusion; Oxford University Press; Cardiovascular Research; 85; 4; 3-2010; 671-680
dc.identifier.issn
0008-6363
dc.identifier.uri
http://hdl.handle.net/11336/61958
dc.description.abstract
AimsMyocardial stunning is a contractile dysfunction that occurs after a brief ischaemic insult. Substantial evidence supports that this dysfunction is triggered by Ca2+ overload during reperfusion. The aim of the present manuscript is to define the origin of this Ca2+ increase in the intact heart.Methods and resultsTo address this issue, Langendorff-perfused mouse hearts positioned on a pulsed local field fluorescence microscope and loaded with fluorescent dyes Rhod-2, Mag-fluo-4, and Di-8-ANEPPS, to assess cytosolic Ca2+, sarcoplasmic reticulum (SR) Ca2+, and transmembrane action potentials (AP), respectively, in the epicardial layer of the hearts, were submitted to 12 min of global ischaemia followed by reperfusion. Ischaemia increased cytosolic Ca2+ in association with a decrease in intracellular Ca2+ transients and a depression of Ca2+ transient kinetics, i.e. the rise time and decay time constant of Ca2+ transients were significantly prolonged. Reperfusion produced a transient increase in cytosolic Ca2+ (Ca2+ bump), which was temporally associated with a decrease in SR-Ca2+ content, as a mirror-like image. Caffeine pulses (20 mM) confirmed that SR-Ca2+ content was greatly diminished at the onset of reflow. The SR-Ca2+ decrease was associated with a decrease in Ca2+ transient amplitude and a shortening of AP duration mainly due to a decrease in phase 2.ConclusionTo the best of our knowledge, this is the first study in which SR-Ca2+ transients are recorded in the intact heart, revealing a previously unknown participation of SR on cytosolic Ca2+ overload upon reperfusion in the intact beating heart. Additionally, the associated shortening of phase 2 of the AP may provide a clue to explain early reperfusion arrhythmias.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Oxford University Press
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Calcium
dc.subject
Fluorescence
dc.subject
Ischaemia/Reperfusion
dc.subject
Sarcoplasmic Reticulum
dc.subject.classification
Fisiología
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dc.subject.classification
Medicina Básica
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Transient Ca2+ depletion of the sarcoplasmic reticulum at the onset of reperfusion
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-09-10T16:44:24Z
dc.journal.volume
85
dc.journal.number
4
dc.journal.pagination
671-680
dc.journal.pais
Reino Unido
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dc.journal.ciudad
Oxford
dc.description.fil
Fil: Valverde, Carlos Alfredo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigaciones Cardiovasculares "Dr. Horacio Eugenio Cingolani". Universidad Nacional de La Plata. Facultad de Ciencias Médicas. Centro de Investigaciones Cardiovasculares "Dr. Horacio Eugenio Cingolani"; Argentina
dc.description.fil
Fil: Kornyeyev, Dmytro. University of California; Estados Unidos
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Fil: Ferreiro, Marcela. University of California; Estados Unidos
dc.description.fil
Fil: Petrosky, Azadé D.. University of California; Estados Unidos
dc.description.fil
Fil: Mattiazzi, Ramona Alicia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigaciones Cardiovasculares "Dr. Horacio Eugenio Cingolani". Universidad Nacional de La Plata. Facultad de Ciencias Médicas. Centro de Investigaciones Cardiovasculares "Dr. Horacio Eugenio Cingolani"; Argentina
dc.description.fil
Fil: Escobar, Ariel Luis Manuel. University of California; Estados Unidos
dc.journal.title
Cardiovascular Research
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.1093/cvr/cvp371
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/cardiovascres/article/85/4/671/297526
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