Artículo
Phospholamban: a tiny protein with a prominent role in the regulation of cardiac relaxation and contractility
Fecha de publicación:
11/2010
Editorial:
SAFIS
Revista:
Physiological Mini-Reviews
ISSN:
1669-5402
e-ISSN:
1669-5410
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Phospholamban (PLN) is a small sarcoplasmic reticulum (SR) protein that in the dephosphorylated state tonically inhibits the SR Ca2+-ATPase (SERCA2a). Different type of evidence to be described, points to PLN as a crucial regulator of basal cardiac Ca2+ cycling, contractility and relaxation and as a main determinant of β -adrenergic stimulatory responses in vivo. The involvement of PLN and PLN phosphorylation under pathological conditions will be also discussed.
Palabras clave:
Phospholamban
,
Cardiac Relaxation
,
Contractility
Archivos asociados
Licencia
Identificadores
Colecciones
Articulos(CIC)
Articulos de CENTRO DE INVEST.CARDIOVASCULARES (I)
Articulos de CENTRO DE INVEST.CARDIOVASCULARES (I)
Citación
Mattiazzi, Ramona Alicia; Mundiña, Cecilia Beatriz; Vittone, Leticia Beatriz; Phospholamban: a tiny protein with a prominent role in the regulation of cardiac
relaxation and contractility; SAFIS; Physiological Mini-Reviews; 5; 3; 11-2010; 8-17
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