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dc.contributor.author
Comellas, Ester  
dc.contributor.author
Gasser, T. Christian  
dc.contributor.author
Bellomo, Facundo Javier  
dc.contributor.author
Oller Martinez, Sergio Horacio  
dc.date.available
2018-10-05T16:49:52Z  
dc.date.issued
2016-03  
dc.identifier.citation
Comellas, Ester; Gasser, T. Christian; Bellomo, Facundo Javier; Oller Martinez, Sergio Horacio; A homeostatic-driven turnover remodelling constitutive model for healing in soft tissues; The Royal Society; Journal of the Royal Society Interface; 13; 116; 3-2016; 1-14  
dc.identifier.issn
1742-5689  
dc.identifier.uri
http://hdl.handle.net/11336/61775  
dc.description.abstract
Remodelling of soft biological tissue is characterized by interacting biochemical and biomechanical events, which change the tissue's microstructure, and, consequently, its macroscopic mechanical properties. Remodelling is a well-defined stage of the healing process, and aims at recovering or repairing the injured extracellular matrix. Like other physiological processes, remodelling is thought to be driven by homeostasis, i.e. it tends to re-establish the properties of the uninjured tissue. However, homeostasis may never be reached, such that remodelling may also appear as a continuous pathological transformation of diseased tissues during aneurysm expansion, for example. A simple constitutive model for soft biological tissues that regards remodelling as homeostatic-driven turnover is developed. Specifically, the recoverable effective tissue damage, whose rate is the sum of a mechanical damage rate and a healing rate, serves as a scalar internal thermodynamic variable. In order to integrate the biochemical and biomechanical aspects of remodelling, the healing rate is, on the one hand, driven by mechanical stimuli, but, on the other hand, subjected to simple metabolic constraints. The proposed model is formulated in accordance with continuum damage mechanics within an open-system thermodynamics framework. The numerical implementation in an in-house finite-element code is described, particularized for Ogden hyperelasticity. Numerical examples illustrate the basic constitutive characteristics of the model and demonstrate its potential in representing aspects of remodelling of soft tissues. Simulation results are verified for their plausibility, but also validated against reported experimental data.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
The Royal Society  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
Constitutive Modelling  
dc.subject
Damage  
dc.subject
Healing  
dc.subject
Remodelling  
dc.subject
Repair  
dc.subject
Soft Tissue  
dc.subject.classification
Otras Ciencias Físicas  
dc.subject.classification
Ciencias Físicas  
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS  
dc.title
A homeostatic-driven turnover remodelling constitutive model for healing in soft tissues  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2018-09-27T15:36:00Z  
dc.journal.volume
13  
dc.journal.number
116  
dc.journal.pagination
1-14  
dc.journal.pais
Reino Unido  
dc.journal.ciudad
Londres  
dc.description.fil
Fil: Comellas, Ester. Universidad Politécnica de Catalunya; España  
dc.description.fil
Fil: Gasser, T. Christian. KTH Royal Institute of Technology; Suecia  
dc.description.fil
Fil: Bellomo, Facundo Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Salta. Instituto de Investigaciones para la Industria Química. Universidad Nacional de Salta. Facultad de Ingeniería. Instituto de Investigaciones para la Industria Química; Argentina  
dc.description.fil
Fil: Oller Martinez, Sergio Horacio. Universidad Politécnica de Catalunya; España  
dc.journal.title
Journal of the Royal Society Interface  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.1098/rsif.2015.1081  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://rsif.royalsocietypublishing.org/content/13/116/20151081