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dc.contributor.author
Llombart, Víctor
dc.contributor.author
Trejo, Sebastian Alejandro
dc.contributor.author
Bronsoms, Sílvia
dc.contributor.author
Morancho, Anna
dc.contributor.author
Feifei, Ma
dc.contributor.author
Faura, Júlia
dc.contributor.author
García Berrocoso, Teresa
dc.contributor.author
Simats, Alba
dc.contributor.author
Rosell, Anna
dc.contributor.author
Canals, Francesc
dc.contributor.author
Hernández Guillamón, Mar
dc.contributor.author
Montaner, Joan
dc.date.available
2018-10-03T19:08:17Z
dc.date.issued
2017-01
dc.identifier.citation
Llombart, Víctor; Trejo, Sebastian Alejandro; Bronsoms, Sílvia; Morancho, Anna; Feifei, Ma; et al.; Profiling and identification of new proteins involved in brain ischemia using MALDI-imaging-mass-spectrometry; Elsevier Science; Journal Of Proteomics; 152; 1-2017; 243-253
dc.identifier.issn
1874-3919
dc.identifier.uri
http://hdl.handle.net/11336/61580
dc.description.abstract
The identification of proteins involved in brain ischemia might allow the discovery of putative biomarkers or therapeutic targets for ischemic stroke. Our aim is to study the distribution of proteins within mouse brain after an ischemic insult using MALDI imaging-mass-spectrometry and to identify relevant proteins involved in brain damage. We occluded the middle cerebral artery of C57BL/6J mice. Brain slices were analyzed by MALDI-TOF and infarct (IC) and contralateral (CL) regions were compared using ClinProTools. The ion distribution maps of relevant m/z values were obtained by FlexImagin3.0. Protein identification was conducted through a bottom-up approach consisting on complementary sample fractionation methods. Some identifications were confirmed by immunohistochemistry and western blot. We identified 102 m/z values with different abundances between IC and CL (p < 0.05), from which 21 m/z peaks were selected as more relevant. Thirteen of them were found increased in the infarct region and 4 m/z values showed AUC > 90% between IC and CL. Identification analyses confirmed altered expressions of ATP5i, COX6C and UMP-CMP kinase in IC compared to CL. Biological significance Using MALDI-IMS we identified for the first time new proteins that might be involved in brain ischemia representing potential diagnostic biomarkers or target molecules for neurological recovery.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier Science
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Biomarkers
dc.subject
Cerebral Ischemia
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Ischemic Stroke
dc.subject
Maldi-Imaging
dc.subject
Tmcao
dc.subject.classification
Salud Ocupacional
dc.subject.classification
Ciencias de la Salud
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Profiling and identification of new proteins involved in brain ischemia using MALDI-imaging-mass-spectrometry
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-09-04T19:56:37Z
dc.journal.volume
152
dc.journal.pagination
243-253
dc.journal.pais
Países Bajos
dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Llombart, Víctor. Universitat Autònoma de Barcelona; España
dc.description.fil
Fil: Trejo, Sebastian Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Universidad Nacional de La Plata. Instituto Multidisciplinario de Biología Celular; Argentina. Universitat Autònoma de Barcelona; España
dc.description.fil
Fil: Bronsoms, Sílvia. Universitat Autònoma de Barcelona; España
dc.description.fil
Fil: Morancho, Anna. Universitat Autònoma de Barcelona; España
dc.description.fil
Fil: Feifei, Ma. Universitat Autònoma de Barcelona; España
dc.description.fil
Fil: Faura, Júlia. Universitat Autònoma de Barcelona; España
dc.description.fil
Fil: García Berrocoso, Teresa. Universitat Autònoma de Barcelona; España
dc.description.fil
Fil: Simats, Alba. Universitat Autònoma de Barcelona; España
dc.description.fil
Fil: Rosell, Anna. Universitat Autònoma de Barcelona; España
dc.description.fil
Fil: Canals, Francesc. Vall d'Hebrón Institute of Oncology; España
dc.description.fil
Fil: Hernández Guillamón, Mar. Universitat Autònoma de Barcelona; España
dc.description.fil
Fil: Montaner, Joan. Universitat Autònoma de Barcelona; España
dc.journal.title
Journal Of Proteomics
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.1016/j.jprot.2016.11.014
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S187439191630481X
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