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Artículo

Unique catanionic vesicles as a potential "nano-Taxi" for drug delivery systems. In vitro and in vivo biocompatibility evaluation

Stagnoli, Antonela SoledadIcon ; Luna, Maria AlejandraIcon ; Villa, Cristian C.; Alustiza, Fabrisio EduardoIcon ; Niebylski, Ana Maria; Moyano, FernandoIcon ; Correa, Nestor MarianoIcon ; Falcone, Ruben DarioIcon
Fecha de publicación: 12/2016
Editorial: Royal Society of Chemistry
Revista: RSC Advances
ISSN: 2046-2069
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Otras Ciencias Químicas

Resumen

We evaluate in vitro and in vivo toxicity and stability in an acidic environment of new vesicles formed by the catanionic surfactant bis(2-ethylhexyl) sulfosuccinate benzyl-n-hexadecyldimethylammonium (AOT-BHD) in order to investigate their potential application as an oral drug delivery system. Unilamellar vesicles were spontaneously formed by dissolving AOT-BHD in water and their toxicity was evaluated through in vitro and in vivo assays. Cell membrane permeability assays (hemolytic activity, Trypan blue assay) and cellular survival or proliferation (MTT assay) were performed. The results showed that only the highest concentration of vesicles tested (2 mg mL-1) diminished the red blood cells' resistance. In vivo toxicity evaluation was carried out on mice through lethal dose 50 (LD50) experiments. The safety for living organisms in doses lower than 0.05 mg mL-1 and the acid pH stability makes our AOT-BHD vesicles a very promising candidate for oral drug delivery.
Palabras clave: Catanionic , Aot-Bhd , Vesicles
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/61519
URL: https://pubs.rsc.org/en/Content/ArticleLanding/2017/RA/C6RA27020D#!divAbstract
DOI: http://dx.doi.org/10.1039/c6ra27020d
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Articulos(CCT - CORDOBA)
Articulos de CTRO.CIENTIFICO TECNOL.CONICET - CORDOBA
Citación
Stagnoli, Antonela Soledad; Luna, Maria Alejandra; Villa, Cristian C.; Alustiza, Fabrisio Eduardo; Niebylski, Ana Maria; et al.; Unique catanionic vesicles as a potential "nano-Taxi" for drug delivery systems. In vitro and in vivo biocompatibility evaluation; Royal Society of Chemistry; RSC Advances; 7; 9; 12-2016; 5372-5380
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