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dc.contributor.author
Morfini, Gerardo Andres
dc.contributor.author
Schmidt, Nadine
dc.contributor.author
Weissmann, Carina
dc.contributor.author
Pigino, Gustavo Fernando
dc.contributor.author
Kins, Stefan
dc.date.available
2018-10-02T15:08:32Z
dc.date.issued
2016-09
dc.identifier.citation
Morfini, Gerardo Andres; Schmidt, Nadine; Weissmann, Carina; Pigino, Gustavo Fernando; Kins, Stefan; Conventional kinesin: Biochemical heterogeneity and functional implications in health and disease; Pergamon-Elsevier Science Ltd; Brain Research Bulletin; 126; 9-2016; 347-353
dc.identifier.issn
0361-9230
dc.identifier.uri
http://hdl.handle.net/11336/61501
dc.description.abstract
Intracellular trafficking events powered by microtubule-based molecular motors facilitate the targeted delivery of selected molecular components to specific neuronal subdomains. Within this context, we provide a brief review of mechanisms underlying the execution of axonal transport (AT) by conventional kinesin, the most abundant kinesin-related motor protein in the mature nervous system. We emphasize the biochemical heterogeneity of this multi-subunit motor protein, further discussing its significance in light of recent discoveries revealing its regulation by various protein kinases. In addition, we raise issues relevant to the mode of conventional kinesin attachment to cargoes and examine recent evidence linking alterations in conventional kinesin phosphorylation to the pathogenesis of adult-onset neurodegenerative diseases.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Pergamon-Elsevier Science Ltd
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Axonal Transport
dc.subject
Kif5
dc.subject
Kinesin
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Kinesin-1
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Klc
dc.subject.classification
Otras Ciencias Biológicas
dc.subject.classification
Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
Conventional kinesin: Biochemical heterogeneity and functional implications in health and disease
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-10-01T16:11:19Z
dc.journal.volume
126
dc.journal.pagination
347-353
dc.journal.pais
Estados Unidos
dc.description.fil
Fil: Morfini, Gerardo Andres. University of Illinois; Estados Unidos
dc.description.fil
Fil: Schmidt, Nadine. University of Kaiserslautern; Alemania
dc.description.fil
Fil: Weissmann, Carina. University of Illinois; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina
dc.description.fil
Fil: Pigino, Gustavo Fernando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina. University of Kaiserslautern; Alemania
dc.description.fil
Fil: Kins, Stefan. University of Kaiserslautern; Alemania
dc.journal.title
Brain Research Bulletin
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.brainresbull.2016.06.009
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0361923016301332
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