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dc.contributor.author
Medina, Marcela Fatima
dc.contributor.author
Cosci, Aldo
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Cisint, Susana Beatriz
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Crespo, Claudia Alejandra
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Ramos, Inés del Carmen
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Iruzubieta Villagra, Ana Lucrecia
dc.contributor.author
Fernandez, Silvia Nelida
dc.date.available
2018-10-01T21:21:33Z
dc.date.issued
2012-09
dc.identifier.citation
Medina, Marcela Fatima; Cosci, Aldo; Cisint, Susana Beatriz; Crespo, Claudia Alejandra; Ramos, Inés del Carmen; et al.; Histopathological and biological studies of the effect of cadmium on Rhinella arenarum gonads; Elsevier; Tissue & Cell; 44; 6; 9-2012; 418-426
dc.identifier.issn
0040-8166
dc.identifier.uri
http://hdl.handle.net/11336/61457
dc.description.abstract
This study was to determine the lethal dose 50 (LD50) of CdCl2 in adult Rhinella arenarum and analyzed the effect of two sublethal doses (0.5 and 5mg/kg) of the xenobiotic in gonads. The 48h LD50 were 50.0 and 49.8mg/kg for males and females respectively. Alterations in the ovary were evidenced by nuclear pleomorphism and cytoplasmic vacuolization of the oocytes at the early stages of development with the highest dose and an increase in the population of atretic oocytes. In the interstitial tissue we noticed congestion, edema and fibroblast proliferation. The nuclear maturation of the oocytes was affected by the xenobiotic in a dose- and time-dependent manner. In males, treatment with 5mg/kg of cadmium (Cd) caused a decrease in the concentration, viability and straight progressive motility of sperm while there was an increase in immotile sperm. Testis histopathology revealed dilated seminiferous tubules, disappearance of cysts, tissue disorganization and leukocyte infiltration. Numerous germ cells showed hydropic tumefaction or signs of focal necrosis. The Cd content in animals intoxicated gonads with the highest sublethal dose was significantly higher than in the control. Results indicate that R. arenarum gonads are target for the xenobiotic, compromising the formation of gametes competent for fertilization, the effective CdCl2 dose being 5mg/kg.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Cadmium
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Gonads
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Reproduction
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Rhinella Arenarum
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Meteorología y Ciencias Atmosféricas
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Ciencias de la Tierra y relacionadas con el Medio Ambiente
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CIENCIAS NATURALES Y EXACTAS
dc.title
Histopathological and biological studies of the effect of cadmium on Rhinella arenarum gonads
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-10-01T15:22:57Z
dc.journal.volume
44
dc.journal.number
6
dc.journal.pagination
418-426
dc.journal.pais
Países Bajos
dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Medina, Marcela Fatima. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; Argentina
dc.description.fil
Fil: Cosci, Aldo. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; Argentina
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Fil: Cisint, Susana Beatriz. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; Argentina
dc.description.fil
Fil: Crespo, Claudia Alejandra. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; Argentina
dc.description.fil
Fil: Ramos, Inés del Carmen. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; Argentina
dc.description.fil
Fil: Iruzubieta Villagra, Ana Lucrecia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; Argentina
dc.description.fil
Fil: Fernandez, Silvia Nelida. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; Argentina
dc.journal.title
Tissue & Cell
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0040816612000791
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.1016/j.tice.2012.08.005
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