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dc.contributor.author
Cartagena, Elena  
dc.contributor.author
Montanaro. Susana  
dc.contributor.author
Bardon, Alicia del Valle  
dc.date.available
2018-09-28T18:10:41Z  
dc.date.issued
2008-10  
dc.identifier.citation
Cartagena, Elena; Montanaro. Susana; Bardon, Alicia del Valle; Improvement of the antibacterial activity of sesquiterpene lactones; Laboratorios Mixim S.A.; Revista Latinoamericana de Quimica; 36; 10-2008; 43-51  
dc.identifier.issn
0370-5943  
dc.identifier.uri
http://hdl.handle.net/11336/61256  
dc.description.abstract
Thirty six sesquiterpene lactones of the guaianolide and germacranolide-type from species of the Tribes Heliantheae and Vernonieae (Asteraceae) were evaluated for their antibacterial action. Thirty of them exhibited selective antibacterial activity, in hole-plate diffusion and liquid media assays, against two strains of Staphylococcus aureus and one of Enterococcus faecalis but resulted inactive on Lactobacillus paracasei, L. plantarum ,Escherichia coli , and Pseudomonas aeruginosa . The most active antibacterial compound was a melampolide-type sesquiterpene lactone, with a MIC = 78 microg/mL, against a methicillin-resistant S. aureus strain. An experimental strategy was also introduced to evaluate the effects of UV light on bacterial growth when certain sesquiterpene lactones were incorporated in hole-plate diffusion assays. Programmed UV irradiation (320-380 nm) during the first two hours of incubation of the agar plates produced increments of the antibacterial activity as a result of the incorporation of certain a, b -unsaturated lactones. In addition, an innovative method to increase the bioavailability of sesquiterpene lactones in antibacterial assays carried out in liquid media is also described. In fact, when polyethyleneglycol 400 (PEG 400) was incorporated (2.5%) to the bacterial cultures, an increment of the antibacterial activity was observed. Finally, hydrogenation of a natural sesquiterpene lactone gave two synthetic analogs whose antibacterial properties were also evaluated in order to set structure-activity relationships.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Laboratorios Mixim S.A.  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
Antibacterial Activity  
dc.subject
Uv Irradiation Effects  
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Sesquiterpene Lactones  
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Heliantheae  
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Vernonieae  
dc.subject.classification
Otras Ciencias Químicas  
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Ciencias Químicas  
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CIENCIAS NATURALES Y EXACTAS  
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Otras Ciencias Biológicas  
dc.subject.classification
Ciencias Biológicas  
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CIENCIAS NATURALES Y EXACTAS  
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Otras Biotecnologías de la Salud  
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Biotecnología de la Salud  
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CIENCIAS MÉDICAS Y DE LA SALUD  
dc.title
Improvement of the antibacterial activity of sesquiterpene lactones  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2018-08-06T14:11:01Z  
dc.journal.volume
36  
dc.journal.pagination
43-51  
dc.journal.pais
México  
dc.journal.ciudad
Naucalpan  
dc.description.fil
Fil: Cartagena, Elena. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; Argentina  
dc.description.fil
Fil: Montanaro. Susana. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; Argentina  
dc.description.fil
Fil: Bardon, Alicia del Valle. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tucumán. Instituto de Química del Noroeste. Grupo Vinculado Unse-inquinoa; Argentina. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; Argentina  
dc.journal.title
Revista Latinoamericana de Quimica