Mostrar el registro sencillo del ítem

dc.contributor.author
Frances, Daniel Eleazar Antonio
dc.contributor.author
Ingaramo, Paola Inés
dc.contributor.author
Ronco, Maria Teresa
dc.contributor.author
Carnovale, Cristina Ester
dc.date.available
2016-06-09T16:13:17Z
dc.date.issued
2013-06
dc.identifier.citation
Frances, Daniel Eleazar Antonio; Ingaramo, Paola Inés; Ronco, Maria Teresa; Carnovale, Cristina Ester; Diabetes, an inflammatory process: Oxidative Stress and TNF-alpha involved in hepatic complication; Scientific Research Publishing; Journal of Biomedical Science and Engineering; 6; 6; 6-2013; 645-653
dc.identifier.issn
1937-6871
dc.identifier.uri
http://hdl.handle.net/11336/6124
dc.description.abstract
Diabetes mellitus (DM) is a serious and growing worldwide health problem and is associated with se- vere acute and chronic complications that negatively influence both quality of life and survival of affected individuals. It is a heterogeneous deregulation of car- bohydrate metabolism. The liver is a central regulator of carbohydrate homeostasis and releases glucose according to metabolic demands. In the last years, the liver injury has been recognized as a major complica- tion of DM. In fact, evidence suggests that in diabetic patients, the mortality rate due to liver cirrhosis is even higher than that due to cardiovascular disease and it has been suggested that there is a two-fold in- creased risk of liver disease in diabetic patients. Among the different types of diabetes, we analyze type 1 dia- betes mellitus as a chronic disorder and an inflam- matory process, which is also associated with in- creased risk of chronic liver injury. Animal models have contributed extensively to the study of diabetes, and it is well established that administration of a unique dose of streptozotocin (STZ) induces insulin- dependent type 1 diabetes mellitus. We analyzed the contribution of Tumor Necrosis Factor alpha (TNF-α) intracellular pathway and oxidative stress in the de- velopment of apoptosis in the liver of streptozotocin- induced diabetic animals. In this review, we describe the role of upstream mediators of the interaction be- tween TNF-α and its receptor, TNF-R1, by assessing the ability of the in vivo treatment with etanercept (TNF-α blocking antibody) to protect against TNF-α- induced apoptosis. Also, we studied the role of iNOS- induction in the TNF-α-induced liver apoptosis by type 1 diabetes, by treatment of diabetic rats with aminoguanidine (selective iNOS inhibitor), which blocked the induction of apoptosis. Interestingly, iNOS inhibition significantly reduced TNF-α levels, evidencing an interaction between TNF-α and iNOS activity. On the other hand, we found that the ad- ministration of antioxidants/hydroxyl radical scaven- gers (Tempol and Desferal) prevented oxidative stress by reducing the effects of hydroxyl radical production and both lipid peroxidation (LPO) levels and apop- tosis. Taken together, our studies support that, at least in part, the hydroxyl radical acts as a reactive inter- mediate, which leads to liver apoptosis in a model of STZ-mediated hyperglycemia. Conclusion and Future: The relevance of the present review is to provide fur- ther knowledge about the mechanisms which may contribute to the disease process in the liver during the course of an inflammatory process as it is type 1 diabetes. Regulation of hepatic TNF-α levels and oxi- dative stress in the diabetic state could be of thera- peutic relevance for the improvement or delay of the hepatic complications linked to chronic hyperglycemia.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Scientific Research Publishing
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Diabetes Mellitus (Dm)
dc.subject
Liver
dc.subject
Apoptosis
dc.subject
Inflammation
dc.subject
Tnf-Α
dc.subject
Inos
dc.subject
Nitric Oxide (No)
dc.subject
Oxidative Stress
dc.subject
Hydroxyl Radical
dc.subject.classification
Endocrinología y Metabolismo
dc.subject.classification
Medicina Clínica
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Diabetes, an inflammatory process: Oxidative Stress and TNF-alpha involved in hepatic complication
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2016-06-01T13:35:32Z
dc.journal.volume
6
dc.journal.number
6
dc.journal.pagination
645-653
dc.journal.pais
Estados Unidos
dc.description.fil
Fil: Frances, Daniel Eleazar Antonio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Rosario. Instituto de Fisiología Experimental (i); Argentina
dc.description.fil
Fil: Ingaramo, Paola Inés. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Rosario. Instituto de Fisiología Experimental (i); Argentina
dc.description.fil
Fil: Ronco, Maria Teresa. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Rosario. Instituto de Fisiología Experimental (i); Argentina
dc.description.fil
Fil: Carnovale, Cristina Ester. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Rosario. Instituto de Fisiología Experimental (i); Argentina
dc.journal.title
Journal of Biomedical Science and Engineering
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.scirp.org/journal/PaperInformation.aspx?PaperID=33682
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.4236/jbise.2013.66079
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/10.4236/jbise.2013.66079