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dc.contributor.author
Bessone, Fernando
dc.contributor.author
Poles, Natalia
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Roma, Marcelo Gabriel
dc.date.available
2016-06-08T14:08:38Z
dc.date.issued
2014-06
dc.identifier.citation
Bessone, Fernando; Poles, Natalia; Roma, Marcelo Gabriel; Challenge of liver disease in systemic lupus erythematosus: Clues for diagnosis and hints for pathogenesis; Baishideng Publishing Group; World Journal of Hepatology; 6; 6; 6-2014; 394-409
dc.identifier.issn
1948-5182
dc.identifier.uri
http://hdl.handle.net/11336/6106
dc.description.abstract
Systemic lupus erythematosus (SLE) encompass a broad spectrum of liver diseases. We propose here to classify them as follows: (1) immunological comorbilities (overlap syndromes); (2) non-immunological comorbilities associated to SLE; and (3) a putative liver damage induced by SLE itself, referred to as “lupus hepatitis”. In the first group, liver injury can be ascribed to overlapping hepatopathies triggered by autoimmune mechanisms other than SLE occurring with higher incidence in the context of lupus (e.g., autoimmune hepatitis, primary biliary cirrhosis). The second group includes non-autoimmune liver diseases, such as esteatosis, hepatitis C, hypercoagulation state-related liver lesions, hyperplasic parenchymal and vascular lesions, porphyria cutanea tarda, and drug-induced hepatotoxicity. Finally, the data in the literature to support the existence of a hepatic disease produced by SLE itself, or the occurrence of a SLE-associated prone condition that increases susceptibility to acquire other liver diseases, is critically discussed. The pathological mechanisms underlying each of these liver disorders are also reviewed. Despite the high heterogeneity in the literature regarding the prevalence of SLE-associated liver diseases and, in most cases, lack of histopathological evidence or clinical studies large enough to support their existence, it is becoming increasingly apparent that liver is an important target of SLE. Consequently, biochemical liver tests should be routinely carried out in SLE patients to discard liver disorders, particularly in those patients chronically exposed to potentially hepatotoxic drugs. Diagnosing liver disease in SLE patients is always challenging, and the systematization of the current information carried out in this review is expected to be of help both to attain a better understanding of pathogenesis and to build an appropriate work-up for diagnosis.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Baishideng Publishing Group
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc/2.5/ar/
dc.subject
Lupus Eritematoso Sistémico
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Hepatitis
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Autoinmunidad
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Hepatotoxicidad
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Gastroenterología y Hepatología
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Medicina Clínica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Challenge of liver disease in systemic lupus erythematosus: Clues for diagnosis and hints for pathogenesis
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2016-06-01T13:47:05Z
dc.journal.volume
6
dc.journal.number
6
dc.journal.pagination
394-409
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Pleasanton
dc.description.fil
Fil: Bessone, Fernando. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Hospital Nacional del Centenario; Argentina
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Fil: Poles, Natalia. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Hospital Nacional del Centenario; Argentina
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Fil: Roma, Marcelo Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Rosario. Instituto de Fisiología Experimental (i); Argentina
dc.journal.title
World Journal of Hepatology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.wjgnet.com/1948-5182/full/v6/i6/394.htm
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/10.4254/wjh.v6.i6.394
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.4254/wjh.v6.i6.394