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dc.contributor.author
Perdomo, Virginia
dc.contributor.author
Rigalli, Juan Pablo
dc.contributor.author
Villanueva, Silvina Stella Maris
dc.contributor.author
Ruiz, Maria Laura
dc.contributor.author
Luquita, Marcelo Gabriel
dc.contributor.author
Echenique, Claudia G.
dc.contributor.author
Catania, Viviana Alicia
dc.date.available
2016-06-08T14:04:47Z
dc.date.issued
2013-10
dc.identifier.citation
Perdomo, Virginia; Rigalli, Juan Pablo; Villanueva, Silvina Stella Maris; Ruiz, Maria Laura; Luquita, Marcelo Gabriel; et al.; Modulation of Biotransformation Systems and ABC Transporters by Benznidazole in Rats; American Society for Microbiology; Antimicrobial Agents and Chemotherapy; 57; 10; 10-2013; 4894-4902
dc.identifier.issn
0066-4804
dc.identifier.uri
http://hdl.handle.net/11336/6105
dc.description.abstract
The effect of antichagasic benznidazole (BZL; 100mg/kg body weight/day, 3 consecutive days, intraperitoneally) on biotransfor-mation systems and ABC transporters was evaluated in rats. Expression of cytochrome P-450 (CYP3A), UDP-glucuronosyltrans-ferase (UGT1A), glutathioneS-transferases (alpha glutathioneS-transferase [GST-], GST-, andGST-), multidrug-resis-tance-associated protein 2 (Mrp2), and P glycoprotein (P-gp) in liver, small intestine, and kidney was estimated by Western blotting. Increases in hepatic CYP3A (30%) andGST-(40%) and in intestinal GST-(72% in jejunumand 136% in ileum) were detected. Significant increases in Mrp2 (300%) and P-gp (500%) proteins in liver from BZL-treated rats were observedwithout changes in kidney. P-gp and Mrp2 were also increased by BZL in jejunum (170%and 120%, respectively). In ileum, only P-gp was increased by BZL (50%). The activities of GST, P-gp, and Mrp2 correlatedwell with the upregulation of proteins in liver and jejunum. Plasma decay of a test dose of BZL (5mg/kg body weight) administered intraduodenally was faster (295%) and the area under the concentration-time curve (AUC) was lower (41%) for BZL-pretreated rats than for controls. The biliary excretion of BZLwas higher (60%) in the BZL group, and urinary excretion of BZL did not showdifferences between groups. The amount of absorbed BZL in intestinal sacs was lower (25%) in pretreated rats than in controls. In conclusion, induction of biotransforma-tion enzymes and/or transporters by BZL could increase the clearance and/or decrease the intestinal absorption of coadminis-tered drugs that are substrates of these systems, including BZL itself.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
American Society for Microbiology
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Benznidazol
dc.subject
Biotransformation
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Abc Transporters
dc.subject
Rats
dc.subject.classification
Farmacología y Farmacia
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Medicina Básica
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Modulation of Biotransformation Systems and ABC Transporters by Benznidazole in Rats
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2016-06-01T13:51:50Z
dc.journal.volume
57
dc.journal.number
10
dc.journal.pagination
4894-4902
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Washington
dc.description.fil
Fil: Perdomo, Virginia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Rosario. Instituto de Fisiología Experimental (i); Argentina
dc.description.fil
Fil: Rigalli, Juan Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Rosario. Instituto de Fisiología Experimental (i); Argentina
dc.description.fil
Fil: Villanueva, Silvina Stella Maris. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Rosario. Instituto de Fisiología Experimental (i); Argentina
dc.description.fil
Fil: Ruiz, Maria Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Rosario. Instituto de Fisiología Experimental (i); Argentina
dc.description.fil
Fil: Luquita, Marcelo Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Rosario. Instituto de Fisiología Experimental (i); Argentina
dc.description.fil
Fil: Echenique, Claudia G.. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; Argentina
dc.description.fil
Fil: Catania, Viviana Alicia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Rosario. Instituto de Fisiología Experimental (i); Argentina
dc.journal.title
Antimicrobial Agents and Chemotherapy
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://aac.asm.org/content/57/10/4894.full
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/10.1128/AAC.02531-12
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1128/AAC.02531-12


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